pH-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy

0369686 - ÚMCH 2012 US eng P - Patent Document
Ulbrich, Karel - Etrych, Tomáš - Říhová, Blanka - Jelínková, Markéta - Kovář, Marek
pH-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy.
Alexandria: United States Patent and Trademark Office, 2011. Owner: Zentiva, k. s. Date of the patent acceptance: 05.04.2011. Patent Number: US7919076
Institutional research plan: CEZ:AV0Z40500505; CEZ:AV0Z50200510
Keywords : cancerostatics * polymer cojugates * targeted therapy
Subject RIV: CC - Organic Chemistry
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Conjugates consisting of a polymeric carrier constituted by 30 to 3,000 monomer units linked to form a polymeric chain, composed of a) 60 to 99% of N-(2-hydroxypropyl)methacrylamide units, b) 1 to 25% of units of methacryloylated hydrazones of .alpha.-amino acids, .epsilon.-amino acids, aromatic amino acids or oligopeptides terminated with a molecule of an anthracycline cancerostatic, c) 0.5 to 15% of units of methacryloylated .alpha.-amino acids, .epsilon.-amino acids, aromatic amino acids or oligopeptides or their sodium salts.
Permanent Link: http://hdl.handle.net/11104/0203694