Výsledky vyhledávání
- 1.0518502 - ÚOCHB 2020 CZ eng A - Abstrakt
Hocková, Dana - Doleželová, Eva - Terán, D. - Špaček, Petr - Česnek, Michal - Gahura, Ondřej - Kotrbová, Zuzana - Keough, D. T. - Zíková, Alena - Guddat, L. W.
Acyclic nucleoside phosphonates as inhibitors of Trypanosoma brucei 6-oxopurine phosphoribosyltransferases.
Liblice 2019. 54th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2019. s. 89.
[Liblice 2019. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /54./. 06.11.2019-08.11.2019, Špindlerův Mlýn]
Grant CEP: GA ČR(CZ) GA16-06049S; GA MŠMT(CZ) LL1205
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303896 - 2.0485092 - ÚOCHB 2018 CN eng A - Abstrakt
Hocková, Dana - Keough, D. T. - Špaček, Petr - Terán, D. - Zíková, Alena - Eng, W. S. - Janeba, Zlatko - Naesens, L. - Chavchich, M. - West, N. P. - Edstein, M. - Guddat, L. W.
Acyclic nucleoside phosphonates (ANPs): Inhibition and structural investigations of 6-oxopurine phosphoribosyltranferases as drug targets.
IDDST 2017. BIT's 15th Annual Congress of International Drug Discovery Science and Technology. Xi'an: BIT, 2017. s. 146.
[IDDST 2017. BIT’s Annual Congress of International Drug Discovery Science and Technology /15./. 09.11.2017-11.11.2017, Xi'an]
Grant CEP: GA ČR(CZ) GA16-06049S; GA MŠMT LL1205
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: enzyme inhibitors * HGPRT * purine salvage pathvay * antiparasitic * prodrugs
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0280304 - 3.0481312 - ÚOCHB 2018 CZ eng A - Abstrakt
Špaček, Petr - Keough, D. T. - Chavchich, M. - Dračínský, Martin - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Guddat, L. W. - Hocková, Dana
Acyclic nucleoside bisphosphonates with asymmetric scaffold as inhibitors of Plasmodial and human 6-oxopurine phosphoribosyltransferases.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 211.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * malaria
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0276898 - 4.0481205 - ÚOCHB 2018 CZ eng A - Abstrakt
Hocková, Dana - Zíková, Alena - Terán, D. - Špaček, Petr - Naesens, L. - Janeba, Zlatko - Keough, D. T. - Guddat, L. W.
Acyclic nucleoside phosphonates: Inhibition and structural investigations of Trypanosoma brucei 6-oxopurine phosphoribosyltranferases.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 148.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
Grant CEP: GA ČR(CZ) GA16-06049S; GA MŠMT LL1205
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: nucleotide analogues * enzyme inhibitors * Trypanosoma brucei
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0276805 - 5.0465091 - ÚOCHB 2017 AU eng A - Abstrakt
Eng, W. S. - Hocková, Dana - Špaček, Petr - Janeba, Zlatko - Rejman, Dominik - West, N. P. - Woods, K. - Naesens, L. - Keough, D. T. - Guddat, L. W.
6-Oxopurine phosphoribosyltransferase as a target for the treatment of human tuberculosis.
International Congress for Tropical Medicine and Malaria 2016. Brisbane: Australian Society for Parasitology, 2016. s. 863.
[ICTMM 2016. International Congress for Tropical Medicine and Malaria /19./. 18.09.2016-22.09.2016, Brisbane]
Institucionální podpora: RVO:61388963
Klíčová slova: HGPRT * enzyme inhibitors * acyclic nucleoside phosphonates
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0263808 - 6.0454303 - ÚOCHB 2016 CZ eng A - Abstrakt
Hocková, Dana - Eng, W. S. - Špaček, Petr - Janeba, Zlatko - West, N. P. - Woods, K. - Naesens, L. M. J. - Keough, D. T. - Guddat, L. W.
Acyclic nucleoside phosphonates as inhibitors of Mycobacterium tuberculosis hypoxanthine-guanine phosphoribosyltransferase: Crystal structures and antituberculosis activity.
Liblice 2015. 50th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2015. s. 74.
[Liblice 2015. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /50./. 06.11.2015-08.11.2015, Olomouc]
Institucionální podpora: RVO:61388963
Klíčová slova: acyclic nucleoside phosphonates * phosphoribosyltransferase * prodrugs
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0256239 - 7.0448777 - ÚOCHB 2016 US eng A - Abstrakt
Špaček, Petr - Keough, D. T. - Janeba, Zlatko - Edstein, M. D. - Chavchich, M. - Wang, T. H. - Guddat, L. W. - Hocková, Dana
Acyclic nucleoside phosphonates containing a second phosphonate group as potent inhibitors of 6-oxopurine phosphoribosyltransferases with antimalarial activity.
25th International Society of Heterocyclic Chemistry Congress. Santa Barbara: International Society of Heterocyclic Chemistry, 2015. 0166.
[International Society of Heterocyclic Chemistry Congress /25./. 23.08.2015-28.08.2015, Santa Barbara]
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * Plasmodium
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0250399 - 8.0445799 - ÚOCHB 2016 US eng A - Abstrakt
Hocková, Dana - Eng, W. S. - Špaček, Petr - Janeba, Zlatko - West, N. P. - Woods, K. - Naesens, L. M. J. - Keough, D. T. - Guddat, L. W.
Acyclic nucleoside phosphonates as inhibitors of mycobacterium tuberculosis hypoxanthine-guanine phosphoribosyltransferase: Crystal structures and antituberculosis activity.
Nucleosides, Nucleotides & Oligonucleotides. Gordon Research Conference 2015. Newport: Gordon Research Conference, 2015.
[Nucleosides, Nucleotides & Oligonucleotides. Gordon Research Conference 2015. 28.06.2015-03.07.2015, Newport]
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * tuberculosis
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0247852 - 9.0422695 - ÚOCHB 2014 FR eng A - Abstrakt
Špaček, Petr - Keough, D. T. - Hocková, Dana - Tichý, Tomáš - Vrbková, Silvie - Slavětínská, Lenka - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Chavchich, M. - Wang, T. - de Jersey, J. - Guddat, L. W.
Acyclic nucleoside phosphonates containing a second phosphonate group as potent inhibitors of 6-oxopurine phosphoribosyltransferases with antimalarial activity.
ESOC 2013. 18th European Symposium on Organic Chemistry. Marseille: -, 2013. s. 183-183.
[ESOC 2013. European Symposium on Organic Chemistry /18./. 07.07.2013-12.07.2013, Marseille]
Grant CEP: GA ČR GAP207/11/0108
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * Plasmodium
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0228958 - 10.0399866 - ÚOCHB 2014 JP eng A - Abstrakt
Hocková, Dana - Keough, D. T. - Špaček, Petr - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Chavchich, M. - Wang, T. H. - de Jersey, J. - Guddat, L. W.
Acyclic nucleoside bisphosphonates as inhibitors of 6-oxopurine phosphoribosyltransferases.
ISNAC 2013. The 40th International Symposium on Nucleic Acid Chemistry. Kanagawa: Kanagawa University, 2013. P004-P004.
[ISNAC 2013. The International Symposium on Nucleic Acid Chemistry /40./. 13.11.2013-15.11.2013, Yokohama]
Grant CEP: GA ČR GAP207/11/0108
Grant ostatní: NHMRC(AU) 1030353
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * plasmodium
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0227081