Výsledky vyhledávání
- 1.0518509 - ÚOCHB 2020 JP eng A - Abstrakt
Skácel, Jan - Keough, D. T. - Guddat, L. W. - Gutten, Ondrej - Hocková, Dana - Janeba, Zlatko
Design and Synthesis of Inhibitors of Enzymes of Purine Metabolism – Application of Direct Metalation of Heterocycles.
27th International Society of Heterocyclic Chemistry Congress. Kyoto: ISHC, 2019. s. 595.
[International Society of Heterocyclic Chemistry Congress /27./. 01.09.2019-06.09.2019, Kyoto]
Grant CEP: GA ČR(CZ) GA16-06049S; GA TA ČR(CZ) TN01000013
Institucionální podpora: RVO:61388963
Klíčová slova: enzyme inhibitior * purine * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303922 - 2.0518502 - ÚOCHB 2020 CZ eng A - Abstrakt
Hocková, Dana - Doleželová, Eva - Terán, D. - Špaček, Petr - Česnek, Michal - Gahura, Ondřej - Kotrbová, Zuzana - Keough, D. T. - Zíková, Alena - Guddat, L. W.
Acyclic nucleoside phosphonates as inhibitors of Trypanosoma brucei 6-oxopurine phosphoribosyltransferases.
Liblice 2019. 54th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2019. s. 89.
[Liblice 2019. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /54./. 06.11.2019-08.11.2019, Špindlerův Mlýn]
Grant CEP: GA ČR(CZ) GA16-06049S; GA MŠMT(CZ) LL1205
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303896 - 3.0518500 - ÚOCHB 2020 CZ eng A - Abstrakt
Klejch, Tomáš - Keough, D. T. - Travis, J. - Janeba, Zlatko - Guddat, L. W. - Hocková, Dana
Alkene Approach to Acyclic Nucleoside Phosphonates: Inhibitors of 6-Oxopurine Phosphoribosyltransferases.
Liblice 2019. 54th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2019. s. 79.
[Liblice 2019. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /54./. 06.11.2019-08.11.2019, Špindlerův Mlýn]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303892 - 4.0518497 - ÚOCHB 2020 TH eng A - Abstrakt
Hocková, Dana - Zíková, Alena - Keough, D. T. - Guddat, L. W.
Modular synthesis of N-branched acyclic nucleoside phosphonates (aza-ANPs) designed as inhibitors of 6-oxopurine phosphoribosyltransferases.
20th Tetrahedron Symposium. Bangkok: Elsevier, 2019. P1.104, „P1014“.
[Tetrahedron Symposium /20./. 18.06.2019-21.06.2019, Bangkok]
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303883 - 5.0500128 - ÚOCHB 2019 JP eng A - Abstrakt
Hocková, Dana - Zíková, Alena - Keough, D. T. - Guddat, L. W.
Modular Synthesis of N-Branched Acyclic Nucleoside Phosphonates (aza-ANPs) Designed as Inhibitors of 6-Oxopurine Phosphoribosyltransferases.
IKCOC-14. 14th International Kyoto Conference on New Aspects of Organic Chemistry. Kyoto: Kyoto University, 2018. s. 80.
[IKCOC-14. International Kyoto Conference on New Aspects of Organic Chemistry /14./. 12.11.2018-16.11.2018, Kyoto]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0292312 - 6.0500089 - ÚOCHB 2019 CZ eng A - Abstrakt
Klejch, Tomáš - Keough, D. T. - Sun, M. - Janeba, Zlatko - Guddat, L. W. - Hocková, Dana
Sulfur Bridged Acyclic Nucleoside Phosphonates as Potential Inhibitors of 6-Oxopurine Phosphoribosyltransferases.
Liblice 2018. 53rd Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2018. s. 91.
[Liblice 2018. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /53./. 02.11.2018-04.11.2018, Lázně Bělohrad]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT * sulfur oxidation
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0292307 - 7.0485092 - ÚOCHB 2018 CN eng A - Abstrakt
Hocková, Dana - Keough, D. T. - Špaček, Petr - Terán, D. - Zíková, Alena - Eng, W. S. - Janeba, Zlatko - Naesens, L. - Chavchich, M. - West, N. P. - Edstein, M. - Guddat, L. W.
Acyclic nucleoside phosphonates (ANPs): Inhibition and structural investigations of 6-oxopurine phosphoribosyltranferases as drug targets.
IDDST 2017. BIT's 15th Annual Congress of International Drug Discovery Science and Technology. Xi'an: BIT, 2017. s. 146.
[IDDST 2017. BIT’s Annual Congress of International Drug Discovery Science and Technology /15./. 09.11.2017-11.11.2017, Xi'an]
Grant CEP: GA ČR(CZ) GA16-06049S; GA MŠMT LL1205
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: enzyme inhibitors * HGPRT * purine salvage pathvay * antiparasitic * prodrugs
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0280304 - 8.0485028 - ÚOCHB 2018 IE eng A - Abstrakt
Kaiser, Martin Maxmilian - Baszczyňski, Ondřej - Hocková, Dana - Poštová Slavětínská, Lenka - Keough, D. T. - Guddat, L. W. - Janeba, Zlatko
Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodial Phosphoribosyltransferases.
BIOHETEROCYCLES 2017. 17th International Conference on Heterocycles in Bioorganic Chemistry. Galway: National University of Ireland, 2017. s. 120.
[BIOHETEROCYCLES 2017. International Conference on Heterocycles in Bioorganic Chemistry /17./. 28.05.2017-31.05.2017, Galway]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: ANPs * plasmodium * HG(X)PRTs * 6-oxo-9-deazapurine
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0280263 - 9.0481312 - ÚOCHB 2018 CZ eng A - Abstrakt
Špaček, Petr - Keough, D. T. - Chavchich, M. - Dračínský, Martin - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Guddat, L. W. - Hocková, Dana
Acyclic nucleoside bisphosphonates with asymmetric scaffold as inhibitors of Plasmodial and human 6-oxopurine phosphoribosyltransferases.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 211.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * malaria
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0276898 - 10.0481306 - ÚOCHB 2018 CZ eng A - Abstrakt
Skácel, Jan - Keough, D. T. - Guddat, L. W. - Janeba, Zlatko - Hocková, Dana
Design and synthesis of potential HG(X)PRT inhibitors based on polysubstituted thiophenes: Utilization of direct metalation of heterocycles.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 205.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * heterocycles
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0276889