Výsledky vyhledávání
- 1.0485092 - ÚOCHB 2018 CN eng A - Abstrakt
Hocková, Dana - Keough, D. T. - Špaček, Petr - Terán, D. - Zíková, Alena - Eng, W. S. - Janeba, Zlatko - Naesens, L. - Chavchich, M. - West, N. P. - Edstein, M. - Guddat, L. W.
Acyclic nucleoside phosphonates (ANPs): Inhibition and structural investigations of 6-oxopurine phosphoribosyltranferases as drug targets.
IDDST 2017. BIT's 15th Annual Congress of International Drug Discovery Science and Technology. Xi'an: BIT, 2017. s. 146.
[IDDST 2017. BIT’s Annual Congress of International Drug Discovery Science and Technology /15./. 09.11.2017-11.11.2017, Xi'an]
Grant CEP: GA ČR(CZ) GA16-06049S; GA MŠMT LL1205
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: enzyme inhibitors * HGPRT * purine salvage pathvay * antiparasitic * prodrugs
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0280304 - 2.0481312 - ÚOCHB 2018 CZ eng A - Abstrakt
Špaček, Petr - Keough, D. T. - Chavchich, M. - Dračínský, Martin - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Guddat, L. W. - Hocková, Dana
Acyclic nucleoside bisphosphonates with asymmetric scaffold as inhibitors of Plasmodial and human 6-oxopurine phosphoribosyltransferases.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 211.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * malaria
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0276898 - 3.0481213 - ÚOCHB 2018 CZ eng A - Abstrakt
Klejch, Tomáš - Keough, D. T. - Naesens, L. - Guddat, L. W. - Janeba, Zlatko - Hocková, Dana
Acyclic nucleoside phosphonates bearing Favipiravir as a nucleobase: Potential inhibitors of hypoxanthine-guanine phosphoribosyltransferase.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 157.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0276814 - 4.0481205 - ÚOCHB 2018 CZ eng A - Abstrakt
Hocková, Dana - Zíková, Alena - Terán, D. - Špaček, Petr - Naesens, L. - Janeba, Zlatko - Keough, D. T. - Guddat, L. W.
Acyclic nucleoside phosphonates: Inhibition and structural investigations of Trypanosoma brucei 6-oxopurine phosphoribosyltranferases.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 148.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
Grant CEP: GA ČR(CZ) GA16-06049S; GA MŠMT LL1205
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: nucleotide analogues * enzyme inhibitors * Trypanosoma brucei
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0276805 - 5.0465091 - ÚOCHB 2017 AU eng A - Abstrakt
Eng, W. S. - Hocková, Dana - Špaček, Petr - Janeba, Zlatko - Rejman, Dominik - West, N. P. - Woods, K. - Naesens, L. - Keough, D. T. - Guddat, L. W.
6-Oxopurine phosphoribosyltransferase as a target for the treatment of human tuberculosis.
International Congress for Tropical Medicine and Malaria 2016. Brisbane: Australian Society for Parasitology, 2016. s. 863.
[ICTMM 2016. International Congress for Tropical Medicine and Malaria /19./. 18.09.2016-22.09.2016, Brisbane]
Institucionální podpora: RVO:61388963
Klíčová slova: HGPRT * enzyme inhibitors * acyclic nucleoside phosphonates
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0263808 - 6.0465089 - ÚOCHB 2017 AU eng A - Abstrakt
Guddat, L. W. - Keough, D. T. - Naesens, L. - Chavchich, M. - Edstein, M. - Hocková, Dana
6-Oxopurine phosphoribosyltransferase as an antimalarial drug target.
International Congress for Tropical Medicine and Malaria 2016. Brisbane: Australian Society for Parasitology, 2016. s. 860.
[ICTMM 2016. International Congress for Tropical Medicine and Malaria /19./. 18.09.2016-22.09.2016, Brisbane]
Institucionální podpora: RVO:61388963
Klíčová slova: HG(X)PRT * enzyme inhibitors * acyclic nucleoside phosphonates
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0263806 - 7.0422695 - ÚOCHB 2014 FR eng A - Abstrakt
Špaček, Petr - Keough, D. T. - Hocková, Dana - Tichý, Tomáš - Vrbková, Silvie - Slavětínská, Lenka - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Chavchich, M. - Wang, T. - de Jersey, J. - Guddat, L. W.
Acyclic nucleoside phosphonates containing a second phosphonate group as potent inhibitors of 6-oxopurine phosphoribosyltransferases with antimalarial activity.
ESOC 2013. 18th European Symposium on Organic Chemistry. Marseille: -, 2013. s. 183-183.
[ESOC 2013. European Symposium on Organic Chemistry /18./. 07.07.2013-12.07.2013, Marseille]
Grant CEP: GA ČR GAP207/11/0108
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * Plasmodium
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0228958 - 8.0407546 - UOCHB-X 970294 NL eng A - Abstrakt
Naesens, L. - Balzarini, J. - De Clercq, E. - Rosenberg, Ivan - Holý, Antonín
Potent and Selective Antiretroviral Activity of 9-(2-Phosphonylmethoxyethyl)-2,6-Diaminopurine (PMEDAP) in Moleney Murine Sarcoma Virus (MSV)-Infected NMRI Mice.
Maastricht, 1989. International TNO Meeting on Animal Models in AIDS. s. P47
[International TNO Meeting on Animal Models in AIDS. 23.10.1989-26.10.1989, Maastricht]
Trvalý link: http://hdl.handle.net/11104/0127651 - 9.0407544 - UOCHB-X 970292 SM eng A - Abstrakt
Balzarini, J. - Naesens, L. - Rosenberg, Ivan - Holý, Antonín - De Clercq, E.
9-(2-Phosphonylmethoxyethyl)-adenine (PMEA) is Superior to 3'-azido-2',3'-dideoxythymidine (AzddThd) as an Anti-Retrovirus Agent "in vivo".
San Marino, 1988. International Symposium on AIDS. s. 108
[International Symposium on Aids. 10.10.1988-14.10.1988, San Marino]
Trvalý link: http://hdl.handle.net/11104/0127649 - 10.0399947 - ÚOCHB 2014 eng A - Abstrakt
Hocková, Dana - Keough, D. T. - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Chavchich, M. - Wang, T. H. - de Jersey, J. - Guddat, L. W.
New Anti-malarial Drug Leads: N-Branched Acyclic Nucleoside Phosphonates as Inhibitors of the Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases.
44th World Chemistry Congress. Istanbul: IUPAC, 2013. s. 1629-1629.
[World Chemistry Congress /44./. 11.08.2013-16.08.2013, Istanbul]
Grant CEP: GA ČR GAP207/11/0108
Grant ostatní: NHMRC(AU) 1030353
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * Plasmodium
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0227125