Výsledky vyhledávání
- 1.0518509 - ÚOCHB 2020 JP eng A - Abstrakt
Skácel, Jan - Keough, D. T. - Guddat, L. W. - Gutten, Ondrej - Hocková, Dana - Janeba, Zlatko
Design and Synthesis of Inhibitors of Enzymes of Purine Metabolism – Application of Direct Metalation of Heterocycles.
27th International Society of Heterocyclic Chemistry Congress. Kyoto: ISHC, 2019. s. 595.
[International Society of Heterocyclic Chemistry Congress /27./. 01.09.2019-06.09.2019, Kyoto]
Grant CEP: GA ČR(CZ) GA16-06049S; GA TA ČR(CZ) TN01000013
Institucionální podpora: RVO:61388963
Klíčová slova: enzyme inhibitior * purine * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303922 - 2.0518499 - ÚOCHB 2020 TH eng A - Abstrakt
Břehová, Petra - Šmídková, Markéta - Skácel, Jan - Dračínský, Martin - Mertlíková-Kaiserová, Helena - Velasquez, M. P. S. - Watts, W. J. - Janeba, Zlatko
Synthesis of acyclic nucleoside phosphonates derived from 2-aminothiazoles and their evaluation as inhibitors of bacterial and human adenylate cyclases.
20th Tetrahedron Symposium. Bangkok: Elsevier, 2019. P1.005, „P1004“.
[Tetrahedron Symposium /20./. 18.06.2019-21.06.2019, Bangkok]
Institucionální podpora: RVO:61388963
Klíčová slova: nucleoside analogues * adenylate cyclases * aminothiazoles
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303890 - 3.0518498 - ÚOCHB 2020 TH eng A - Abstrakt
Česnek, Michal - Šafránek, Michal - Skácel, Jan - Dračínský, Martin - Mertlíková-Kaiserová, Helena - Velasquez, M. P. S. - Watts, W. J. - Janeba, Zlatko
Synthesis of 5-[2-(phosphonomethoxy)ethyl] (PME) derivatives of 4-substituted 2-aminothiazoles as potential inhibitors of bacterial and human adenylate cyclases.
20th Tetrahedron Symposium. Bangkok: Elsevier, 2019. P1.005, „P1005“.
[Tetrahedron Symposium /20./. 18.06.2019-21.06.2019, Bangkok]
Institucionální podpora: RVO:61388963
Klíčová slova: adenylate cyclases * aminothiazoles
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303886 - 4.0506263 - ÚOCHB 2020 CZ eng A - Abstrakt
Skácel, Jan - Baszczyňski, Ondřej - Mertlíková-Kaiserová, Helena - Tloušťová, Eva - Pachl, Petr - Maloy Řezáčová, Pavlína - Snášel, Jan - Pichová, Iva - Janeba, Zlatko
Development of purine nucleoside phosphorylase inhibitors as potential anticancer therapeutics.
Czech Chemical Society Symposium Series. Roč. 17, č. 1 (2019), s. 34. ISSN 2336-7202.
[Interdisciplinary Meeting of Young Researchers and Students in the Field of Chemistry, Biochemistry, Molecular Biology, and Biomaterials /19./. 20.05.2019-23.05.2019, Milovy]
Grant CEP: GA TA ČR(CZ) TN01000013
Institucionální podpora: RVO:61388963
Klíčová slova: PNP * anticancer therapeutics
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0297752 - 5.0485126 - ÚOCHB 2018 DE eng A - Abstrakt
Skácel, Jan - Hocková, Dana - Janeba, Zlatko
Synthesis of tetra-Substituted Thiophenes via Direct Metalation.
26th ISHC Congress. Regensburg: International Society of Heterocyclic Chemistry, 2017. s. 358.
[ISHC Congress /26./. 03.09.2017-08.09.2017, Regensburg]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: thiophenes * metalation * HG(X)PRT
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0280336 - 6.0481306 - ÚOCHB 2018 CZ eng A - Abstrakt
Skácel, Jan - Keough, D. T. - Guddat, L. W. - Janeba, Zlatko - Hocková, Dana
Design and synthesis of potential HG(X)PRT inhibitors based on polysubstituted thiophenes: Utilization of direct metalation of heterocycles.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 205.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * heterocycles
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0276889 - 7.0481189 - ÚOCHB 2018 CZ eng A - Abstrakt
Břehová, Petra - Šmídková, Markéta - Skácel, Jan - Dračínský, Martin - Mertlíková-Kaiserová, Helena - Velasquez, M. P. S. - Watts, V. J. - Janeba, Zlatko
Synthesis of acyclic nucleoside phosphonates with unnatural heterocyclic bases bearing aryl substituents and their inhibitory activity towards bacterial and human adenylate cyclases.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 125.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
Grant CEP: GA MV VG20102015046
Institucionální podpora: RVO:61388963
Klíčová slova: acyclic nucleoside phosphonates (ANPs) * adenylate cyclase toxin (ACT) * Bordetella pertussis
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0276789 - 8.0464963 - ÚOCHB 2017 ES eng A - Abstrakt
Břehová, Petra - Šmídková, Markéta - Mertlíková-Kaiserová, Helena - Skácel, Jan - Dračínský, Martin - Janeba, Zlatko
Synthesis of acyclic nucleoside phosphonates bearing aryl substituent at the acyclic linker as potential inhibitors of adenylate cyclase toxin from Bordetella pertussis.
17th Tetrahedron Symposium. Challenges in Biological, Bioorganic, Organic and Medicinal Chemistry. Sitges: Elsevier, 2016.
[Tetrahedron Symposium. Challenges in Biological, Bioorganic, Organic and Medicinal Chemistry /17./. 28.06.2016-01.07.2016, Sitges]
Grant CEP: GA MV VG20102015046
Institucionální podpora: RVO:61388963
Klíčová slova: acyclic nucleoside phosphonates (ANPs) * adenylate cyclase toxin (ACT) * Bordetella pertussis
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0263697