Výsledky vyhledávání
- 1.0510479 - ÚOCHB 2020 RIV FR eng J - Článek v odborném periodiku
Klejch, Tomáš - Keough, D. T. - Chavchich, M. - Travis, J. - Skácel, Jan - Pohl, Radek - Janeba, Zlatko - Edstein, M. D. - Avery, V. M. - Guddat, L. W. - Hocková, Dana
Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.
European Journal of Medicinal Chemistry. Roč. 183, Dec 1 (2019), č. článku 111667. ISSN 0223-5234. E-ISSN 1768-3254
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: hypoxanthine-guanine-xanthine phosphoribosyltransferase * sulfur-containing drugs * sulfide oxidation * Plasmodium falciparum * acyclic nucleoside phosphonates
Obor OECD: Organic chemistry
Impakt faktor: 5.573, rok: 2019
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/abs/pii/S0223523419308116?via%3Dihub
Trvalý link: http://hdl.handle.net/11104/0300951 - 2.0498922 - BC 2019 RIV US eng J - Článek v odborném periodiku
Doleželová, Eva - Terán, D. - Gahura, Ondřej - Kotrbová, Zuzana - Procházková, Michaela - Keough, D. T. - Špaček, Petr - Hocková, Dana - Guddat, L. - Zíková, Alena
Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.
PLoS Neglected Tropical Diseases. Roč. 12, č. 2 (2018), č. článku e0006301. ISSN 1935-2735. E-ISSN 1935-2735
Grant CEP: GA ČR(CZ) GA16-06049S; GA MŠMT LL1205
Institucionální podpora: RVO:60077344 ; RVO:61388963
Klíčová slova: hypoxanthine-guanine phosphoribosyltransferase * acyclic nucleoside phosphonates * human african trypanosomiasis * inducible expression system * purine salvage * plasmodium-falciparum * crystal-structures * xanthine phosphoribosyltransferase * mycobacterium-tuberculosis * antimalarial activity
Obor OECD: Microbiology; Organic chemistry (UOCHB-X)
Impakt faktor: 4.487, rok: 2018
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006301
Trvalý link: http://hdl.handle.net/11104/0291797 - 3.0495494 - ÚOCHB 2019 RIV GB eng J - Článek v odborném periodiku
Klejch, Tomáš - Pohl, Radek - Janeba, Zlatko - Sun, M. - Keough, D. T. - Guddat, L. W. - Hocková, Dana
Acyclic nucleoside phosphonates with unnatural nucleobases, favipiravir and allopurinol, designed as potential inhibitors of the human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases.
Tetrahedron. Roč. 74, č. 40 (2018), s. 5886-5897. ISSN 0040-4020. E-ISSN 1464-5416
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: hypoxanthine-guanine-xanthine phosphoribosyltransferase * regioselective Mitsunobu reaction * acyclic nucleotide analogues * enzyme inhibition
Obor OECD: Organic chemistry
Impakt faktor: 2.379, rok: 2018
Trvalý link: http://hdl.handle.net/11104/0288465 - 4.0489497 - ÚOCHB 2019 RIV US eng J - Článek v odborném periodiku
Keough, D. T. - Rejman, Dominik - Pohl, Radek - Zborníková, Eva - Hocková, Dana - Croll, T. - Edstein, M. D. - Birrell, G. W. - Chavchich, M. - Naesens, L. M. J. - Pierens, G. K. - Brereton, I. M. - Guddat, L. W.
Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.
ACS Chemical Biology. Roč. 13, č. 1 (2018), s. 82-90. ISSN 1554-8929. E-ISSN 1554-8937
Grant CEP: GA ČR(CZ) GA16-06049S; GA ČR GA15-11711S
Institucionální podpora: RVO:61388963
Klíčová slova: plasmodium vivax * inhibitor * pyrrolidine nucleotide bisphosphonate * HXGPRT
Obor OECD: Organic chemistry
Impakt faktor: 4.374, rok: 2018
Trvalý link: http://hdl.handle.net/11104/0283906 - 5.0479744 - ÚOCHB 2018 RIV US eng J - Článek v odborném periodiku
Špaček, Petr - Keough, D. T. - Chavchich, M. - Dračínský, Martin - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Guddat, L. W. - Hocková, Dana
Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.
Journal of Medicinal Chemistry. Roč. 60, č. 17 (2017), s. 7539-7554. ISSN 0022-2623. E-ISSN 1520-4804
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: hypoxanthine-guanine phosphoribosyltransferase * 2nd phosphonate group * 6-oxopurine phosphoribosyltransferases
Obor OECD: Organic chemistry
Impakt faktor: 6.253, rok: 2017
Trvalý link: http://hdl.handle.net/11104/0275689 - 6.0478407 - ÚOCHB 2018 RIV DE eng J - Článek v odborném periodiku
Kaiser, Martin Maxmilian - Baszczyňski, Ondřej - Hocková, Dana - Poštová Slavětínská, Lenka - Dračínský, Martin - Keough, D. T. - Guddat, L. W. - Janeba, Zlatko
Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine and a Five-Membered Heterocycle as Selective Inhibitors of Plasmodial 6-Oxopurine Phosphoribosyltransferases.
ChemMedChem. Roč. 12, č. 14 (2017), s. 1133-1141. ISSN 1860-7179. E-ISSN 1860-7187
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: inhibitors * nucleosides * malaria * phosphonates * purine salvage
Obor OECD: Organic chemistry
Impakt faktor: 3.009, rok: 2017
Trvalý link: http://hdl.handle.net/11104/0274530 - 7.0477558 - ÚOCHB 2018 RIV GB eng J - Článek v odborném periodiku
Špaček, Petr - Keough, D. T. - Chavchich, M. - Dračínský, Martin - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Guddat, L. W. - Hocková, Dana
Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs.
Bioorganic & Medicinal Chemistry. Roč. 25, č. 15 (2017), s. 4008-4030. ISSN 0968-0896. E-ISSN 1464-3391
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: enzyme inhibitors * nucleotide analogues * malaria
Obor OECD: Organic chemistry
Impakt faktor: 2.881, rok: 2017
Trvalý link: http://hdl.handle.net/11104/0273877 - 8.0475283 - ÚOCHB 2018 RIV FR eng J - Článek v odborném periodiku
Eng, W. S. - Keough, D. T. - Hocková, Dana - Winzor, D. J. - Guddat, L. W.
Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochimie. Roč. 135, Apr (2017), s. 6-14. ISSN 0300-9084. E-ISSN 1638-6183
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: enzyme inhibitors * acyclic nucleoside phosphonates * 6-oxopurine phosphoribosyltransferase
Obor OECD: Organic chemistry
Impakt faktor: 3.188, rok: 2017
Trvalý link: http://hdl.handle.net/11104/0272121 - 9.0474802 - ÚOCHB 2018 RIV GB eng J - Článek v odborném periodiku
Lukáč, Miloš - Hocková, Dana - Keough, D. T. - Guddat, L. W. - Janeba, Zlatko
Novel nucleotide analogues bearing (1H-1,2,3-triazol-4-yl)phosphonic acid moiety as inhibitors of Plasmodium and human 6-oxopurine phosphoribosyltransferases.
Tetrahedron. Roč. 73, č. 6 (2017), s. 692-702. ISSN 0040-4020. E-ISSN 1464-5416
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: acyclic nucleoside phosphonates * 6-oxopurine * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * copper(I)-catalyzed azide-alkyne cycloaddition
Obor OECD: Organic chemistry
Impakt faktor: 2.377, rok: 2017
Trvalý link: http://hdl.handle.net/11104/0271755 - 10.0469893 - ÚOCHB 2017 RIV DE eng J - Článek v odborném periodiku
Eng, W. S. - Hocková, Dana - Špaček, Petr - Baszczyňski, Ondřej - Janeba, Zlatko - Naesens, L. - Keough, D. T. - Guddat, L. W.
Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase.
ChemistrySelect. Roč. 1, č. 19 (2016), s. 6267-6276. ISSN 2365-6549. E-ISSN 2365-6549
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: enzyme inhibitors * nucleotide analogues * HPRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0267662