Výsledky vyhledávání
- 1.0518502 - ÚOCHB 2020 CZ eng A - Abstrakt
Hocková, Dana - Doleželová, Eva - Terán, D. - Špaček, Petr - Česnek, Michal - Gahura, Ondřej - Kotrbová, Zuzana - Keough, D. T. - Zíková, Alena - Guddat, L. W.
Acyclic nucleoside phosphonates as inhibitors of Trypanosoma brucei 6-oxopurine phosphoribosyltransferases.
Liblice 2019. 54th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2019. s. 89.
[Liblice 2019. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /54./. 06.11.2019-08.11.2019, Špindlerův Mlýn]
Grant CEP: GA ČR(CZ) GA16-06049S; GA MŠMT(CZ) LL1205
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303896 - 2.0518500 - ÚOCHB 2020 CZ eng A - Abstrakt
Klejch, Tomáš - Keough, D. T. - Travis, J. - Janeba, Zlatko - Guddat, L. W. - Hocková, Dana
Alkene Approach to Acyclic Nucleoside Phosphonates: Inhibitors of 6-Oxopurine Phosphoribosyltransferases.
Liblice 2019. 54th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2019. s. 79.
[Liblice 2019. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /54./. 06.11.2019-08.11.2019, Špindlerův Mlýn]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303892 - 3.0500128 - ÚOCHB 2019 JP eng A - Abstrakt
Hocková, Dana - Zíková, Alena - Keough, D. T. - Guddat, L. W.
Modular Synthesis of N-Branched Acyclic Nucleoside Phosphonates (aza-ANPs) Designed as Inhibitors of 6-Oxopurine Phosphoribosyltransferases.
IKCOC-14. 14th International Kyoto Conference on New Aspects of Organic Chemistry. Kyoto: Kyoto University, 2018. s. 80.
[IKCOC-14. International Kyoto Conference on New Aspects of Organic Chemistry /14./. 12.11.2018-16.11.2018, Kyoto]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0292312 - 4.0485126 - ÚOCHB 2018 DE eng A - Abstrakt
Skácel, Jan - Hocková, Dana - Janeba, Zlatko
Synthesis of tetra-Substituted Thiophenes via Direct Metalation.
26th ISHC Congress. Regensburg: International Society of Heterocyclic Chemistry, 2017. s. 358.
[ISHC Congress /26./. 03.09.2017-08.09.2017, Regensburg]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: thiophenes * metalation * HG(X)PRT
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0280336 - 5.0485092 - ÚOCHB 2018 CN eng A - Abstrakt
Hocková, Dana - Keough, D. T. - Špaček, Petr - Terán, D. - Zíková, Alena - Eng, W. S. - Janeba, Zlatko - Naesens, L. - Chavchich, M. - West, N. P. - Edstein, M. - Guddat, L. W.
Acyclic nucleoside phosphonates (ANPs): Inhibition and structural investigations of 6-oxopurine phosphoribosyltranferases as drug targets.
IDDST 2017. BIT's 15th Annual Congress of International Drug Discovery Science and Technology. Xi'an: BIT, 2017. s. 146.
[IDDST 2017. BIT’s Annual Congress of International Drug Discovery Science and Technology /15./. 09.11.2017-11.11.2017, Xi'an]
Grant CEP: GA ČR(CZ) GA16-06049S; GA MŠMT LL1205
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: enzyme inhibitors * HGPRT * purine salvage pathvay * antiparasitic * prodrugs
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0280304 - 6.0485030 - ÚOCHB 2018 IE eng A - Abstrakt
Kolman, Viktor - Kalčic, Filip - Zídek, Zdeněk - Janeba, Zlatko
Polysubstituted 2-Aminopyrimidines as Inhibitors of Prostaglandin E2 Production.
BIOHETEROCYCLES 2017. 17th International Conference on Heterocycles in Bioorganic Chemistry. Galway: National University of Ireland, 2017. s. 131.
[BIOHETEROCYCLES 2017. International Conference on Heterocycles in Bioorganic Chemistry /17./. 28.05.2017-31.05.2017, Galway]
Grant CEP: GA TA ČR(CZ) TE01020028
Institucionální podpora: RVO:61388963 ; RVO:68378041
Klíčová slova: pyrimidines * anti-inflammatory * prostaglandin E2
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0280266 - 7.0485028 - ÚOCHB 2018 IE eng A - Abstrakt
Kaiser, Martin Maxmilian - Baszczyňski, Ondřej - Hocková, Dana - Poštová Slavětínská, Lenka - Keough, D. T. - Guddat, L. W. - Janeba, Zlatko
Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodial Phosphoribosyltransferases.
BIOHETEROCYCLES 2017. 17th International Conference on Heterocycles in Bioorganic Chemistry. Galway: National University of Ireland, 2017. s. 120.
[BIOHETEROCYCLES 2017. International Conference on Heterocycles in Bioorganic Chemistry /17./. 28.05.2017-31.05.2017, Galway]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: ANPs * plasmodium * HG(X)PRTs * 6-oxo-9-deazapurine
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0280263 - 8.0481312 - ÚOCHB 2018 CZ eng A - Abstrakt
Špaček, Petr - Keough, D. T. - Chavchich, M. - Dračínský, Martin - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Guddat, L. W. - Hocková, Dana
Acyclic nucleoside bisphosphonates with asymmetric scaffold as inhibitors of Plasmodial and human 6-oxopurine phosphoribosyltransferases.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 211.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * malaria
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0276898 - 9.0481306 - ÚOCHB 2018 CZ eng A - Abstrakt
Skácel, Jan - Keough, D. T. - Guddat, L. W. - Janeba, Zlatko - Hocková, Dana
Design and synthesis of potential HG(X)PRT inhibitors based on polysubstituted thiophenes: Utilization of direct metalation of heterocycles.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 205.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * heterocycles
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0276889 - 10.0481213 - ÚOCHB 2018 CZ eng A - Abstrakt
Klejch, Tomáš - Keough, D. T. - Naesens, L. - Guddat, L. W. - Janeba, Zlatko - Hocková, Dana
Acyclic nucleoside phosphonates bearing Favipiravir as a nucleobase: Potential inhibitors of hypoxanthine-guanine phosphoribosyltransferase.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 157.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0276814