Výsledky vyhledávání
- 1.0518502 - ÚOCHB 2020 CZ eng A - Abstrakt
Hocková, Dana - Doleželová, Eva - Terán, D. - Špaček, Petr - Česnek, Michal - Gahura, Ondřej - Kotrbová, Zuzana - Keough, D. T. - Zíková, Alena - Guddat, L. W.
Acyclic nucleoside phosphonates as inhibitors of Trypanosoma brucei 6-oxopurine phosphoribosyltransferases.
Liblice 2019. 54th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2019. s. 89.
[Liblice 2019. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /54./. 06.11.2019-08.11.2019, Špindlerův Mlýn]
Grant CEP: GA ČR(CZ) GA16-06049S; GA MŠMT(CZ) LL1205
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303896 - 2.0518498 - ÚOCHB 2020 TH eng A - Abstrakt
Česnek, Michal - Šafránek, Michal - Skácel, Jan - Dračínský, Martin - Mertlíková-Kaiserová, Helena - Velasquez, M. P. S. - Watts, W. J. - Janeba, Zlatko
Synthesis of 5-[2-(phosphonomethoxy)ethyl] (PME) derivatives of 4-substituted 2-aminothiazoles as potential inhibitors of bacterial and human adenylate cyclases.
20th Tetrahedron Symposium. Bangkok: Elsevier, 2019. P1.005, „P1005“.
[Tetrahedron Symposium /20./. 18.06.2019-21.06.2019, Bangkok]
Institucionální podpora: RVO:61388963
Klíčová slova: adenylate cyclases * aminothiazoles
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303886 - 3.0481195 - ÚOCHB 2018 CZ eng A - Abstrakt
Česnek, Michal - Dračínský, Martin - Šmídková, Markéta - Mertlíková-Kaiserová, Helena - Velasquez, M. P. S. - Watts, V. J. - Janeba, Zlatko
Synthesis and evaluation of novel acyclic nucleoside phosphonates with unnatural nucleobases as potent inhibitors of Bordetella pertussis adenylate cyclase toxin.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 128.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
Grant CEP: GA MV VG20102015046
Institucionální podpora: RVO:61388963
Klíčová slova: acyclic nucleoside phosphonates (ANPs) * adenylate cyclase toxin (ACT) * Bordetella pertussis
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0276795 - 4.0468400 - ÚOCHB 2017 DK eng A - Abstrakt
Terán, D. - Hocková, Dana - Česnek, Michal - Keough, D. T. - Guddat, L. W.
Crystal structures of Trypanosoma brucei hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Acta Crystallographica Section A. Oxford Blackwell. Roč. 72, Suppl. (2016), S207. ISSN 0108-7673. E-ISSN 2053-2733.
[European Crystallographic Meeting /30./. 28.08.2016-01.09.2016, Basel]
Institucionální podpora: RVO:61388963
Klíčová slova: 6-oxopurine phosphoribosyltransferase * enzyme inhibitors * acyclic nucleoside phosphonates
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0266258 - 5.0465086 - ÚOCHB 2017 AU eng A - Abstrakt
Terán, D. - Hocková, Dana - Česnek, Michal - Keough, D. T. - Guddat, L. W.
Crystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase.
International Congress for Tropical Medicine and Malaria 2016. Brisbane: Australian Society for Parasitology, 2016. s. 435.
[ICTMM 2016. International Congress for Tropical Medicine and Malaria /19./. 18.09.2016-22.09.2016, Brisbane]
Institucionální podpora: RVO:61388963
Klíčová slova: HGPRT * enzyme inhibitors * acyclic nucleoside phosphonates
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0263804 - 6.0464964 - ÚOCHB 2017 ES eng A - Abstrakt
Česnek, Michal - Šmídková, Markéta - Dračínský, Martin - Janeba, Zlatko
Novel acyclic nucleoside phosphonates containing unnatural nucleobases as potent inhibitors of Bordetella pertussis adenylyl cyclase toxin.
17th Tetrahedron Symposium. Challenges in Biological, Bioorganic, Organic and Medicinal Chemistry. Sitges: Elsevier, 2016.
[Tetrahedron Symposium. Challenges in Biological, Bioorganic, Organic and Medicinal Chemistry /17./. 28.06.2016-01.07.2016, Sitges]
Grant CEP: GA MV VG20102015046
Institucionální podpora: RVO:61388963
Klíčová slova: acyclic nucleoside phosphonates (ANPs) * adenylate cyclase toxin (ACT) * Bordetella pertussis
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0263704 - 7.0442819 - ÚOCHB 2016 GB eng A - Abstrakt
Šmídková, Markéta - Dvořáková, Alexandra - Tloušťová, Eva - Česnek, Michal - Janeba, Zlatko - Mertlíková-Kaiserová, Helena
Amidate prodrugs of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as inhibitors of adenylate cyclase toxin from Bordetella pertussis.
FEBS Journal. Roč. 281, Suppl S1 (2014), s. 729. ISSN 1742-464X. E-ISSN 1742-4658.
[FEBS EMBO 2014 Conference. 30.08.2014-04.09.2014, Paris]
Grant CEP: GA MŠMT LO1302; GA MV VG20102015046
Institucionální podpora: RVO:61388963
Klíčová slova: Bordetella pertussis * adenylyl cyclase toxin * inhibitors
Kód oboru RIV: CE - Biochemie
Trvalý link: http://hdl.handle.net/11104/0245642 - 8.0422674 - ÚOCHB 2014 FR eng A - Abstrakt
Česnek, Michal - Jansa, Petr - Dračínský, Martin - Šmídková, Markéta - Dvořáková, Alexandra - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
Synthesis and biological evaluation of 2-substituted 9-[2-(phosphonomethoxy)ethyl]adenine derivatives.
ESOC 2013. 18th European Symposium on Organic Chemistry. Marseille: -, 2013. s. 85-85.
[ESOC 2013. European Symposium on Organic Chemistry /18./. 07.07.2013-12.07.2013, Marseille]
Grant CEP: GA MV VG20102015046
Institucionální podpora: RVO:61388963
Klíčová slova: PMEA * adenylyl cyclase toxin * phosphonate
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0228952 - 9.0399048 - ÚOCHB 2014 US eng A - Abstrakt
Mandíková, J. - Volková, M. - Pávek, P. - Česnek, Michal - Janeba, Zlatko - Trejtnar, F.
Interactions of acyclic nucleoside phosphonates with selected renal SLC and ABC transporters.
26th International Conference on Antiviral Research (ICAR). San Francisco: International Society for Antiviral Research (ISAR), 2013. s. 101-101.
[International Conference on Antiviral Research /26./. 11.05.2013-15.05.2013, San Francisco]
Institucionální podpora: RVO:61388963
Klíčová slova: acyclic nucleoside phosphonates * antiviral * organic anion transporters * nephrotoxicity
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0226443 - 10.0384671 - ÚOCHB 2013 ES eng A - Abstrakt
Česnek, Michal - Jansa, Petr - Holý, Antonín - Dračínský, Martin - Baszczyňski, Ondřej - Janeba, Zlatko
Efficient and ‘green’ microwave-assisted synthesis of haloalkylphosphonates via Michaelis-Arbuzov reaction.
Zing Conferences: Microwave and Flow Conference. Lanzarote: -, 2012. s. 50-50.
[Zing Conferences: Microwave and Flow Conference. 28.02.2012-02.03.2012, Lanzarote]
Grant CEP: GA MŠMT 1M0508; GA AV ČR 1QS400550501
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: microwave-assisted * Michaelis Arbuzov * phosphonates
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0214240