Výsledky vyhledávání
- 1.0542010 - ÚOCHB 2022 RIV FR eng J - Článek v odborném periodiku
Frydrych, Jan - Keough, D. T. - Chavchich, M. - Travis, J. - Dračínský, Martin - Edstein, M. D. - Guddat, L. W. - Hocková, Dana - Janeba, Zlatko
Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
European Journal of Medicinal Chemistry. Roč. 219, Jul 5 (2021), č. článku 113416. ISSN 0223-5234. E-ISSN 1768-3254
Grant CEP: GA ČR(CZ) GA19-07707S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleoside phosphonates * phosphoroamidate prodrug * HG(X)PRT * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * Plasmodium falciparum * Plasmodium vivax
Obor OECD: Organic chemistry
Impakt faktor: 7.088, rok: 2021
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.ejmech.2021.113416
Trvalý link: http://hdl.handle.net/11104/0319509 - 2.0518509 - ÚOCHB 2020 JP eng A - Abstrakt
Skácel, Jan - Keough, D. T. - Guddat, L. W. - Gutten, Ondrej - Hocková, Dana - Janeba, Zlatko
Design and Synthesis of Inhibitors of Enzymes of Purine Metabolism – Application of Direct Metalation of Heterocycles.
27th International Society of Heterocyclic Chemistry Congress. Kyoto: ISHC, 2019. s. 595.
[International Society of Heterocyclic Chemistry Congress /27./. 01.09.2019-06.09.2019, Kyoto]
Grant CEP: GA ČR(CZ) GA16-06049S; GA TA ČR(CZ) TN01000013
Institucionální podpora: RVO:61388963
Klíčová slova: enzyme inhibitior * purine * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303922 - 3.0518502 - ÚOCHB 2020 CZ eng A - Abstrakt
Hocková, Dana - Doleželová, Eva - Terán, D. - Špaček, Petr - Česnek, Michal - Gahura, Ondřej - Kotrbová, Zuzana - Keough, D. T. - Zíková, Alena - Guddat, L. W.
Acyclic nucleoside phosphonates as inhibitors of Trypanosoma brucei 6-oxopurine phosphoribosyltransferases.
Liblice 2019. 54th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2019. s. 89.
[Liblice 2019. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /54./. 06.11.2019-08.11.2019, Špindlerův Mlýn]
Grant CEP: GA ČR(CZ) GA16-06049S; GA MŠMT(CZ) LL1205
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303896 - 4.0518500 - ÚOCHB 2020 CZ eng A - Abstrakt
Klejch, Tomáš - Keough, D. T. - Travis, J. - Janeba, Zlatko - Guddat, L. W. - Hocková, Dana
Alkene Approach to Acyclic Nucleoside Phosphonates: Inhibitors of 6-Oxopurine Phosphoribosyltransferases.
Liblice 2019. 54th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2019. s. 79.
[Liblice 2019. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /54./. 06.11.2019-08.11.2019, Špindlerův Mlýn]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303892 - 5.0518497 - ÚOCHB 2020 TH eng A - Abstrakt
Hocková, Dana - Zíková, Alena - Keough, D. T. - Guddat, L. W.
Modular synthesis of N-branched acyclic nucleoside phosphonates (aza-ANPs) designed as inhibitors of 6-oxopurine phosphoribosyltransferases.
20th Tetrahedron Symposium. Bangkok: Elsevier, 2019. P1.104, „P1014“.
[Tetrahedron Symposium /20./. 18.06.2019-21.06.2019, Bangkok]
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0303883 - 6.0500128 - ÚOCHB 2019 JP eng A - Abstrakt
Hocková, Dana - Zíková, Alena - Keough, D. T. - Guddat, L. W.
Modular Synthesis of N-Branched Acyclic Nucleoside Phosphonates (aza-ANPs) Designed as Inhibitors of 6-Oxopurine Phosphoribosyltransferases.
IKCOC-14. 14th International Kyoto Conference on New Aspects of Organic Chemistry. Kyoto: Kyoto University, 2018. s. 80.
[IKCOC-14. International Kyoto Conference on New Aspects of Organic Chemistry /14./. 12.11.2018-16.11.2018, Kyoto]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0292312 - 7.0500089 - ÚOCHB 2019 CZ eng A - Abstrakt
Klejch, Tomáš - Keough, D. T. - Sun, M. - Janeba, Zlatko - Guddat, L. W. - Hocková, Dana
Sulfur Bridged Acyclic Nucleoside Phosphonates as Potential Inhibitors of 6-Oxopurine Phosphoribosyltransferases.
Liblice 2018. 53rd Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2018. s. 91.
[Liblice 2018. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /53./. 02.11.2018-04.11.2018, Lázně Bělohrad]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT * sulfur oxidation
Obor OECD: Organic chemistry
Trvalý link: http://hdl.handle.net/11104/0292307 - 8.0485126 - ÚOCHB 2018 DE eng A - Abstrakt
Skácel, Jan - Hocková, Dana - Janeba, Zlatko
Synthesis of tetra-Substituted Thiophenes via Direct Metalation.
26th ISHC Congress. Regensburg: International Society of Heterocyclic Chemistry, 2017. s. 358.
[ISHC Congress /26./. 03.09.2017-08.09.2017, Regensburg]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: thiophenes * metalation * HG(X)PRT
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0280336 - 9.0481213 - ÚOCHB 2018 CZ eng A - Abstrakt
Klejch, Tomáš - Keough, D. T. - Naesens, L. - Guddat, L. W. - Janeba, Zlatko - Hocková, Dana
Acyclic nucleoside phosphonates bearing Favipiravir as a nucleobase: Potential inhibitors of hypoxanthine-guanine phosphoribosyltransferase.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 157.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
Grant CEP: GA ČR(CZ) GA16-06049S
Institucionální podpora: RVO:61388963
Klíčová slova: nucleotide analogues * enzyme inhibitors * HG(X)PRT
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0276814 - 10.0465089 - ÚOCHB 2017 AU eng A - Abstrakt
Guddat, L. W. - Keough, D. T. - Naesens, L. - Chavchich, M. - Edstein, M. - Hocková, Dana
6-Oxopurine phosphoribosyltransferase as an antimalarial drug target.
International Congress for Tropical Medicine and Malaria 2016. Brisbane: Australian Society for Parasitology, 2016. s. 860.
[ICTMM 2016. International Congress for Tropical Medicine and Malaria /19./. 18.09.2016-22.09.2016, Brisbane]
Institucionální podpora: RVO:61388963
Klíčová slova: HG(X)PRT * enzyme inhibitors * acyclic nucleoside phosphonates
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0263806