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0427937 - BFÚ 2015 RIV PL eng J - Článek v odborném periodiku
Hofer, Michal - Pospíšil, Milan - Dušek, L. - Hoferová, Zuzana - Komůrková, Denisa
Combined pharmacological therapy of the acute radiation disease using a cyclooxygenase-2 inhibitor and an adenosine A(3) receptor agonist.
Central European Journal of Biology. Roč. 9, č. 6 (2014), s. 642-646. ISSN 1895-104X
Grant CEP: GA ČR(CZ) GAP303/11/0128
Institucionální podpora: RVO:68081707
Klíčová slova: Hematopoiesis * Cyclooxygenase inhibition * Adenosine receptor agonist
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 0.710, rok: 2014

Combined approaches to the treatment of acute radiation disease are preferred to single-agent therapies due to proven or anticipated better outcomes comprising increased therapeutic efficacy and decreased incidence of undesirable side effects. Our studies on post-exposure treatment of mice irradiated by sublethal or lethal doses of ionizing radiation included testing the effectiveness of meloxicam, a cyclooxygenase-2 inhibitor, and IB-MECA, an adenosine A3 receptor agonist. The efficacy of meloxicam and IB-MECA to positively influence the progress of the acute radiation disease has been tested in situations of their combined administration with granulocyte colony-stimulating factor (G-CSF) or with each other. The results of our studies revealed a significantly improved regeneration of hematopoietic cell populations ranging from the bone marrow progenitor cells to mature blood cells following combined treatments. Also, survival of mice exposed to lethal radiation doses was highest in the animals treated with a combination of the two drugs.
Trvalý link: http://hdl.handle.net/11104/0233386
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0452276 - ÚPT 2016 RIV HU eng C - Konferenční příspěvek (zahraniční konf.)
Skoupý, Radim - Krzyžánek, Vladislav - Kočová, L. - Nebesářová, Jana
Electron beam induced mass loss dependence on aging of Epon resin sections.
12th Multinational Congress on Microscopy. Budapest: Akadémiai Kiadó, 2015, s. 112-113. ISBN 978-963-05-9653-4.
[MCM 2015. Multinational Congress on Microscopy /12./. Eger (HU), 23.08.2015-28.08.2015]
Grant CEP: GA ČR(CZ) GA14-20012S; GA MŠMT(CZ) LO1212; GA MŠMT ED0017/01/01
Institucionální podpora: RVO:68081731 ; RVO:60077344
Klíčová slova: STEM * mass loss * resin * Epon
Kód oboru RIV: JA - Elektronika a optoelektronika, elektrotechnika

It has been recently shown that low voltage STEM (Scanning Transmission Electron Microscope) can be regarded as the method of choice for many studies of biological samples. Main advantage of this technique is that it allows one to image samples with low contrast. Usually, in a standard STEM (typical acceleration voltage 60–300 kV) the image contrast is enhanced by staining using salts of heavy metals (e.g., uranyl acetate, lead citrate). This is not necessarily in low voltage STEM. Consequently, investigated structures are closer to native state of investigated samples. During sample preparation biological material is embedded in a resin which is observed in microscope in a form of ultrathin sections. There is commercially available wide spectrum of resins with different properties for embedding samples in a range from soft tissues to bones. They have various parameters such as hardness, mechanical stability, penetrability. For imaging an important parameter is a sensitivity to degradation by electron beam.
Trvalý link: http://hdl.handle.net/11104/0253305