Počet záznamů: 1
Hematopoietic Cytokine Gene Duplication in Zebrafish Erythroid and Myeloid Lineages
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SYSNO ASEP 0501983 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Hematopoietic Cytokine Gene Duplication in Zebrafish Erythroid and Myeloid Lineages Tvůrce(i) Oltová, Jana (UMG-J)
Svoboda, Ondřej (UMG-J)
Bartůněk, Petr (UMG-J) RIDCelkový počet autorů 3 Číslo článku 174 Zdroj.dok. Frontiers in Cell and Developmental Biology. - : Frontiers Research Foundation - ISSN 2296-634X
Roč. 6, December (2018)Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova zebrafish ; hematopoiesis ; cytokine ; genome duplication ; myelopoiesis ; erythropoiesis Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemistry and molecular biology CEP LO1419 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA16-21024S GA ČR - Grantová agentura ČR Institucionální podpora UMG-J - RVO:68378050 UT WOS 000455439700001 DOI 10.3389/fcell.2018.00174 Anotace Hematopoiesis is a precisely orchestrated process regulated by the activity of hematopoietic cytokines and their respective receptors. Due to an extra round of whole genome duplication during vertebrate evolution in teleost fish, zebrafish have two paralogs of many important genes, including genes involved in hematopoiesis. Importantly, these duplication events brought increased level of complexity in such cases, where both ligands and receptors have been duplicated in parallel. Therefore, precise understanding of binding specificities between duplicated ligand-receptor signalosomes as well as understanding of their differential expression provide an important basis for future studies to better understand the role of duplication of these genes. However, although many recent studies in the field have partly addressed functional redundancy or sub-specialization of some of those duplicated paralogs, this information remains to be scattered over many publications and unpublished data. Therefore, the focus of this review is to provide an overview of recent findings in the zebrafish hematopoietic field regarding activity, role and specificity of some of the hematopoietic cytokines with emphasis on crucial regulators of the erythro-myeloid lineages. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2019
Počet záznamů: 1