Počet záznamů: 1
Rational design of sensor for broadband dielectric spectroscopy of biomolecules
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SYSNO ASEP 0490476 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Rational design of sensor for broadband dielectric spectroscopy of biomolecules Tvůrce(i) Havelka, Daniel (URE-Y) RID
Krivosudský, Ondrej (URE-Y)
Průša, Jiří (URE-Y)
Cifra, Michal (URE-Y) RID, ORCID, SAICelkový počet autorů 4 Zdroj.dok. Sensors and Actuators B - Chemical. - : Elsevier
Roč. 273, 10 November (2018), s. 62-69Poč.str. 8 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova High-frequency biosensors ; Molecular dynamics ; Dielectric spectroscopy Vědní obor RIV JA - Elektronika a optoelektronika, elektrotechnika Obor OECD Electrical and electronic engineering CEP GA15-17102S GA ČR - Grantová agentura ČR Institucionální podpora URE-Y - RVO:67985882 UT WOS 000441519000009 EID SCOPUS 85048328061 DOI 10.1016/j.snb.2018.05.124 Anotace Knowledge of electromagnetic properties of biomolecules is essential for a fundamental understanding of electric field interaction with biosystems and for development of novel biomedical diagnostic and therapeutic methods. To enable systematic analysis of the dielectric properties of biomolecule solutions we presented here a method for a rational design of radiofrequency and microwave chip for quantitative dielectric sensing. At first, we estimated the primary frequency band of interest using a relaxation time of targeted molecule via the Stokes–Einstein–Debye equation. Then we proposed a microwave sensing chip for the estimated frequency band and evaluated its performance using both analytical modeling and numerical electromagnetic simulations. We fabricated the chip and experimentally demonstrated that we can extract the complex permittivity (0.5–40 GHz) of the water solution of alanine – one of the most common proteinogenic amino acids – without any calibration liquid and with about 20-fold smaller volume than with commercial methods. The observed dependence of extracted complex permittivity on the alanine concentration was interpreted using molecular dynamics simulations. The procedure we described here can be applied for the development of dielectric sensing method of any polar biomolecule solution Pracoviště Ústav fotoniky a elektroniky Kontakt Petr Vacek, vacek@ufe.cz, Tel.: 266 773 413, 266 773 438, 266 773 488 Rok sběru 2019
Počet záznamů: 1