Počet záznamů: 1
Metabolism of ibuprofen in higher plants: A model Arabidopsis thaliana cell suspension culture system
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SYSNO ASEP 0481319 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Metabolism of ibuprofen in higher plants: A model Arabidopsis thaliana cell suspension culture system Tvůrce(i) Maršík, Petr (UEB-Q) RID, ORCID
Šíša, Miroslav (UEB-Q) ORCID
Lacina, O. (CZ)
Moťková, Kateřina (UEB-Q) ORCID
Langhansová, Lenka (UEB-Q) RID, ORCID
Rezek, Jan (UEB-Q) RID, ORCID
Vaněk, Tomáš (UEB-Q) RID, ORCIDCelkový počet autorů 7 Zdroj.dok. Environmental Pollution. - : Elsevier - ISSN 0269-7491
Roč. 220, JAN (2017), s. 383-392Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Arabidopsis thaliana ; Ibuprofen ; Metabolism ; Plant cells ; Sequestration Vědní obor RIV CE - Biochemie Obor OECD Plant sciences, botany CEP GA14-22593S GA ČR - Grantová agentura ČR Institucionální podpora UEB-Q - RVO:61389030 UT WOS 000390736700041 EID SCOPUS 84992163553 DOI 10.1016/j.envpol.2016.09.074 Anotace The uptake and metabolism of ibuprofen (IBU) by plants at the cellular level was investigated using a suspension culture of A. thaliana. Almost all IBU added to the medium (200 μM) was metabolized or bound to insoluble structures in 5 days. More than 300 metabolites were determined by liquid chromatography-high resolution mass spectrometry (LC-HRMS) analysis, and most of these are first reported for plants here. Although hydroxylated derivatives formed by oxidation on the isobutyl side chain were the main first-step products of IBU degradation, conjugates of these products with sugar, methyl and amino acid groups were the dominant metabolites in the culture. The main portion of total added IBU (81%) was accumulated in the extractable intracellular pool, whereas the cultivation medium fraction contained only 19%. The amount of the insoluble cell-wall-bound IBU was negligible (0.005% of total IBU). Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2018
Počet záznamů: 1