Počet záznamů: 1
Alterations in Outer Membrane Permeability Favor Drug-Resistant Phenotype of Klebsiella pneumoniae
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SYSNO ASEP 0476610 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Alterations in Outer Membrane Permeability Favor Drug-Resistant Phenotype of Klebsiella pneumoniae Tvůrce(i) Pulzová, L. (SK)
Navrátilová, Lucie (UEB-Q) ORCID
Comor, L. (SK)Celkový počet autorů 3 Zdroj.dok. Microbial Drug Resistance-Mechanisms Epidemiology and Disease. - : Mary Ann Liebert - ISSN 1076-6294
Roč. 23, č. 4 (2017), s. 413-420Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova drug resistance ; efflux pumps ; influx ; Klebsiella ; porin Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology Institucionální podpora UEB-Q - RVO:61389030 UT WOS 000402567800002 EID SCOPUS 85020207434 DOI 10.1089/mdr.2016.0017 Anotace The increasing number of infections caused by multidrug-resistant and pandrug-resistant bacteria represents a serious worlwide problem. Drug resistance limits available antimicrobials and can lead to suboptimal treatment of bacterial infections. It can be predicted that resistance to more antimicrobial drugs will be acquired by even more bacteria in the future. Among the distinct resistance strategies, preventing drug entrance to intracellular compartment through modification of membrane permeability (bacterial influx) and active export of compounds to the external environment (bacterial efflux) are of particular importance as they limit the interaction of the drug with its intracellular targets and, consequently, its deleterious effects on the cell. Several current studies have extended our understanding of drug resistance mechanisms associated with altered membrane permeability in gram-negative bacteria. In this study, we propose a summary of resistance mechanisms associated with transport of drugs across bacterial cell envelope exploited by Klebsiella pneumoniae, one of the most common nosocomial infection-causing pathogens. The better understanding of molecular bases of drug transport in/out of the single cell may have consequence for success in antimicrobial therapy of infection caused by drug-resistant Klebsiella. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2018
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