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Myrica rubra leaves as a potential source of a dual 5-LOX/COX inhibitor
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SYSNO ASEP 0474824 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Myrica rubra leaves as a potential source of a dual 5-LOX/COX inhibitor Tvůrce(i) Langhansová, Lenka (UEB-Q) RID, ORCID
Landa, Přemysl (UEB-Q) RID, ORCID
Kutil, Zsófia (UEB-Q)
Tauchen, Jan (UEB-Q)
Maršík, Petr (UEB-Q) RID, ORCID
Rezek, Jan (UEB-Q) RID, ORCID
Lou, J.D. (CN)
Yun, Z.L. (CN)
Vaněk, Tomáš (UEB-Q) RID, ORCIDCelkový počet autorů 9 Zdroj.dok. Food and Agricultural Immunology - ISSN 0954-0105
Roč. 28, č. 2 (2017), s. 343-353Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova in-vitro ; antiinflammatory activity ; zucc. leaves ; 5-lipoxygenase ; sieb. ; cyclooxygenase ; constituents ; antioxidants ; myricitrin ; metabolism ; Myrica rubra ; anti-inflammatory ; cyclooxygenase 1 ; cyclooxygenase 2 ; 5-lipoxygenase Vědní obor RIV FR - Farmakologie a lékárnická chemie Obor OECD Medicinal chemistry CEP LH12165 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA16-07193S GA ČR - Grantová agentura ČR Institucionální podpora UEB-Q - RVO:61389030 UT WOS 000394647700015 DOI 10.1080/09540105.2016.1272554 Anotace Myrica rubra Sieb. et Zucc. is a valuable fruit tree that is used in Chinese, Japanese and Taiwanese traditional medicine. We investigated the anti-inflammatory activity of M. rubra leaves extracted with four different solvents. Total phenolics were determined using the Folin-Ciocalteu method. Extracts were investigated for their inhibitory activity toward the pro-inflammatory enzymes cyclooxygenase-1 and2 (COX-1, COX-2) and 5-lipoxygenase (5-LOX). The ethanol extract of M. rubra leaves demonstrated a strong inhibition of prostaglandin E-2 (PGE(2)) biosynthesis catalyzed by both COX-1 (93.42%) and COX-2 (75.71%) and leukotriene B-4 (LTB4) formation catalyzed by 5-LOX (82.72%). Further we identified selective COX-1 inhibition by the n-butanol and aqueous fractions of the ethanol extract (with an IC50 for COX-1 inhibition of 1.07 and 0.71 mu gmL(-1) (,) respectively) and dual 5-LOX/COX inhibition by the ethyl acetate fraction (with an IC50 of 3.29 for COX-1, 2.54 for COX-2 and 8.30 mu gmL(-1) for 5-LOX). Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2018
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