Počet záznamů: 1
In vitro antioxidant and anti-proliferative activity of Ethiopian medicinal plant extracts
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SYSNO ASEP 0448068 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název In vitro antioxidant and anti-proliferative activity of Ethiopian medicinal plant extracts Tvůrce(i) Tauchen, J. (CZ)
Doskočil, I. (CZ)
Caffi, C. (BE)
Lulekal, E. (ET)
Maršík, Petr (UEB-Q) RID, ORCID
Havlík, J. (CZ)
Van Damme, P. (BE)
Kokoška, L. (CZ)Zdroj.dok. Industrial Crops and Products. - : Elsevier - ISSN 0926-6690
Roč. 74, NOV 15 (2015), s. 671-679Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Antioxidant ; Anticarcinogenic ; Plant extract Vědní obor RIV GM - Potravinářství Institucionální podpora UEB-Q - RVO:61389030 UT WOS 000360948900086 DOI 10.1016/j.indcrop.2015.05.068 Anotace Identification and characterization of natural products with antioxidant and anti-proliferative activity has received much interest over the past few years. Ethiopia is one of the developing countries which have enormous diversity of plants and yet majority stays scientifically neglected and undiscovered. In this study, the ethanol extracts of 18 Ethiopian wild medicinal plants were investigated for their in vitro antioxidant and anti-proliferative potential. For this purpose DPPH (2,2-diphenyl-1-picrylhydrazyl), ORAC (oxygen radical absorbance capacity) and TPC (total phenolic content) assays together with MU cell viability assay (performed on Hep-G2 and MRC-5) were used. Extracts of Carissa spinarum, Dodonaea angustifolia, Jasminum abyssinicum, Rumex nepalensis, Rubus steudneri and Verbascum sinaiticum exhibited the most significant results. However, it was discovered that C. spinarum, J. abyssinicum and R. steudneri possessed considerable toxicity against normal MRC-5 cell line. Only extracts of D. angustifolia and R. nepalensis demonstrated significant combinatory antioxidant/anti-proliferative effect, while V. sinaiticum showed best selective anti-proliferative activity. Since aforementioned extracts also exerted low or minimal toxicity to normal cells, we suggest these as prospective material for further development of novel plant-based agents effective against oxidative stress related diseases. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2016
Počet záznamů: 1