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New approaches to the synthesis of sildenafil analogues and their enzyme inhibitory activity
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SYSNO ASEP 0446637 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název New approaches to the synthesis of sildenafil analogues and their enzyme inhibitory activity Tvůrce(i) Mojzych, M. (PL)
Karczmarzyk, Z. (PL)
Wysocki, W. (PL)
Ceruso, M. (IT)
Supuran, C.T. (IT)
Kryštof, Vladimír (UEB-Q) RID, ORCID
Urbanczyk-Lipkowska, Z. (PL)
Kalicki, P. (PL)Zdroj.dok. Bioorganic & Medicinal Chemistry. - : Elsevier - ISSN 0968-0896
Roč. 23, č. 7 (2015), s. 1421-1429Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Sildenafil analogues ; Pyrazolo[4,3-e][1,2,4] triazine ; Sulfonamides Vědní obor RIV CE - Biochemie CEP GAP305/12/0783 GA ČR - Grantová agentura ČR Institucionální podpora UEB-Q - RVO:61389030 UT WOS 000350995500006 DOI 10.1016/j.bmc.2015.02.026 Anotace In the search for new biologically active chemotypes, several sildenafil analogs were prepared and characterized. The presence of the pyrazolo[4,3-e][1,2,4] triazine core is thought to be of interest for the enzyme inhibitory activity of these compounds. The designed derivatives incorporating the sildenafil scaffold were assayed as carbonic anhydrase inhibitors, and for their cytotoxic activity against MCF-7 and K562 cell lines. The X-ray analysis of one of these model compounds was performed and its crystal structure is described/compared to that of sildenafil. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2016
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