Počet záznamů: 1
Electro-Acoustic Behavior of the Mitotic Spindle: A Semi-Classical Coarse-Grained Model
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SYSNO ASEP 0428315 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Electro-Acoustic Behavior of the Mitotic Spindle: A Semi-Classical Coarse-Grained Model Tvůrce(i) Havelka, Daniel (URE-Y) RID
Kučera, Ondřej (URE-Y) RID
Deriu, M.A. (CH)
Cifra, Michal (URE-Y) RID, ORCID, SAICelkový počet autorů 4 Zdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 9, č. 1 (2014), e86501Poč.str. 13 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova electric fields ; tubulin ; chromosomes Vědní obor RIV JA - Elektronika a optoelektronika, elektrotechnika CEP GAP102/11/0649 GA ČR - Grantová agentura ČR Institucionální podpora URE-Y - RVO:67985882 UT WOS 000330617100018 DOI 10.1371/journal.pone.0086501 Anotace The regulation of chromosome separation during mitosis is not fully understood yet. Microtubules forming mitotic spindles are targets of treatment strategies which are aimed at (i) the triggering of the apoptosis or (ii) the interruption of uncontrolled cell division. Despite these facts, only few physical models relating to the dynamics of mitotic spindles exist up to now. In this paper, we present the first electromechanical model which enables calculation of the electromagnetic field coupled to acoustic vibrations of the mitotic spindle. This electromagnetic field originates from the electrical polarity of microtubules which form the mitotic spindle. The model is based on the approximation of resonantly vibrating microtubules by a network of oscillating electric dipoles. Our computational results predict the existence of a rapidly changing electric field which is generated by either driven or endogenous vibrations of the mitotic spindle. For certain values of parameters, the intensity of the electric field and its gradient reach values which may exert a not-inconsiderable force on chromosomes which are aligned in the spindle midzone. Our model may describe possible mechanisms of the effects of ultra-short electrical and mechanical pulses on dividing cells-a strategy used in novel methods for cancer treatment Pracoviště Ústav fotoniky a elektroniky Kontakt Petr Vacek, vacek@ufe.cz, Tel.: 266 773 413, 266 773 438, 266 773 488 Rok sběru 2015
Počet záznamů: 1