Počet záznamů: 1
Tumour-inhibitory and antimetastatic effects of IL-2 in mice carrying MHC class I- tumours of HPV16 origin
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SYSNO ASEP 0191662 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Tumour-inhibitory and antimetastatic effects of IL-2 in mice carrying MHC class I- tumours of HPV16 origin Tvůrce(i) Indrová, Marie (UMG-J) RID
Bubeník, Jan (UMG-J)
Mikyšková, Romana (UMG-J) RID
Vonka, V. (CZ)
Šmahel, M. (CZ)
Žák, R. (CZ)
Šímová, Jana (UMG-J) RID
Bieblová, Jana (UMG-J)
Mendoza, Luis (UMG-J)
Jandlová, Táňa (UMG-J)Zdroj.dok. International Journal of Oncology. - : Spandidos Publications - ISSN 1019-6439
Roč. 2002, č. 20 (2002), s. 643-646Poč.str. 4 s. Jazyk dok. eng - angličtina Země vyd. GR - Řecko Klíč. slova HPV16, IL-2 ; tumour vaccines ; gene therapy Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z5052915 - UMG-J Anotace Oncogenic, moderately immunogenic, MHC class I- and class II-, B7(-), MK16/l/III ABC (MK16) cells were previously established by co-transfection of HPV16 E6/E7 and activated H-ras oncogene DNA into C57BL/6 kidney cells. Subcutaneous transplantation of these cells produced progressively growing local neoplasms which metastasized spontaneously to lungs and lymph nodes. The MK16 cells were implanted into syngeneic mice and used to examine whether the tumour lacking the signal molecules required for the induction of and sensitivity to T cell immunity is susceptible to local IL-2 treatment and IL-2 gene therapy. Peritumoural administration of human rIL-2 or murine IL-2 gene-modified MK16 tumour vaccine inhibited growth of subcutaneous MK16 tumour transplants and reduced the number of their lung metastases. These results indicate that experimental tumours which are MHC class I- and mimick in this respect a high proportion of human HPV16-associated carcinomas are suitable for IL-2 treatment. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2004
Počet záznamů: 1