Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2
1.
SYSNO ASEP
0173739
Druh ASEP
J - Článek v odborném periodiku
Zařazení RIV
J - Článek v odborném periodiku
Poddruh J
Ostatní články
Název
Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2
Tvůrce(i)
Bryja, Vítězslav (UEM-P) Sedláček, J. (CZ) Zahradníčková, E. (CZ) Ševčíková, S. (CZ) Pacherník, J. (CZ) Souček, K. (CZ) Hofmanová, J. (CZ) Kozubík, A. (CZ) Šmarda, J. (CZ)
Zdroj.dok.
Prostaglandins & Other Lipid Mediators. - : Elsevier
- ISSN 1098-8823
Roč. 72, - (2003), s. 131-145
Poč.str.
15 s.
Jazyk dok.
eng - angličtina
Země vyd.
US - Spojené státy americké
Klíč. slova
hematopoiesis
Vědní obor RIV
EB - Genetika a molekulární biologie
CEP
GA301/01/0040 GA ČR - Grantová agentura ČR
GA524/03/0766 GA ČR - Grantová agentura ČR
CEZ
AV0Z5039906 - UEM-P
MSM 14300008
Anotace
In this study lipoxygenase inhibitors were used to study the role of arachidonic acid metabolism in regulation of proliferation and apoptosis of chicken monoblasts BM2 and its functional interaction with Jun proteins. It was demonstrated that lipoxygenase inhibitors further enforce tumor suppresive capabilities of Jun proteins by inducing either more efficient cell cycle block and/or apoptosis in BM2 cells. This suggests that there is a crosstalk between the lipoxygenase- and Jun-directed pathways in regulation of proliferation and differentiation of leukemic cells.
