Počet záznamů: 1
Platinum(IV) Derivatives of [Pt(1iS/i,2iS/i-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells
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SYSNO ASEP 0583634 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Platinum(IV) Derivatives of [Pt(1iS/i,2iS/i-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells Tvůrce(i) Kostrhunová, Hana (BFU-R) RID, ORCID
McGhie, B. S. (AU)
Marková, Lenka (BFU-R) ORCID
Nováková, Olga (BFU-R) RID, ORCID
Kašpárková, Jana (BFU-R) RID, ORCID
Aldrich-Wright, J.R. (AU)
Brabec, Viktor (BFU-R) RID, ORCIDCelkový počet autorů 7 Zdroj.dok. Journal of Medicinal Chemistry. - : American Chemical Society - ISSN 0022-2623
Roč. 66, č. 12 (2023), s. 7894-7908Poč.str. 15 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova cyclooxygenase inhibitors ; anticancer activity ; in-vitro ; death ; complexes ; mechanism ; cisplatin ; mitochondrial ; cytotoxicity Vědní obor RIV FR - Farmakologie a lékárnická chemie Obor OECD Inorganic and nuclear chemistry CEP GA21-27514S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora BFU-R - RVO:68081707 UT WOS 001006562300001 EID SCOPUS 85163517797 DOI 10.1021/acs.jmedchem.3c00269 Anotace The platinum(II) complex [Pt(1S,2S-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)](2+) (Pt(II)56MeSS, 1) exhibits high potencyacross numerous cancer cell lines acting by a multimodal mechanism.However, 1 also displays side toxicity and in vivo activity,all details of its mechanism of action are not entirely clear. Here,we describe the synthesis and biological properties of new platinum(IV)prodrugs that combine 1 with one or two axially coordinatedmolecules of diclofenac (DCF), a non-steroidal anti-inflammatory cancer-selectivedrug. The results suggest that these Pt(IV) complexes exhibit mechanismsof action typical for Pt(II) complex 1 and DCF, simultaneously.The presence of DCF ligand(s) in the Pt(IV) complexes promotes theantiproliferative activity and selectivity of 1 by inhibitinglactate transporters, resulting in blockage of the glycolytic processand impairment of mitochondrial potential. Additionally, the investigatedPt(IV) complexes selectively induce cell death in cancer cells, andthe Pt(IV) complexes containing DCF ligands induce hallmarks of immunogeniccell death in cancer cells. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2024 Elektronická adresa https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00269
Počet záznamů: 1