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Current Approaches to Wound Repair in Burns: How far we Have Come From Cover to Close? A Narrative Review
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SYSNO ASEP 0583345 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve SCOPUS Název Current Approaches to Wound Repair in Burns: How far we Have Come From Cover to Close? A Narrative Review Tvůrce(i) Šuca, H. (CZ)
Čoma, M. (SK)
Tomšů, Júlia (FGU-C)
Sabová, J. (SK)
Zajíček, R. (CZ)
Brož, Antonín (FGU-C) RID, ORCID, SAI
Doubková, Martina (FGU-C) ORCID, RID
Novotný, T. (CZ)
Bačáková, Lucie (FGU-C) RID, ORCID
Jenčová, V. (CZ)
Kuželová Košťáková, E. (CZ)
Lukačín, Š. (SK)
Rejman, Dominik (UOCHB-X) RID, ORCID
Gál, P. (CZ)Zdroj.dok. Journal of Surgical Research. - : Elsevier - ISSN 0022-4804
Roč. 296, April (2024), s. 383-403Poč.str. 21 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova regeneration ; scar ; skin ; wound dressing ; wound healing Obor OECD Cell biology CEP NU22-06-00016 GA MZd - Ministerstvo zdravotnictví LX22NPO5103 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA22-08857S GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 ; UOCHB-X - RVO:61388963 EID SCOPUS 85185179580 DOI 10.1016/j.jss.2023.12.043 Anotace Burn injuries are a significant global health concern, with more than 11 million people requiring medical intervention each year and approximately 180,000 deaths annually. Despite progress in health and social care, burn injuries continue to result in socioeconomic burdens for victims and their families. The management of severe burn injuries involves preventing and treating burn shock and promoting skin repair through a two-step procedure of covering and closing the wound. Currently, split-thickness/full-thickness skin autografts are the gold standard for permanent skin substitution. However, deep burns treated with split-thickness skin autografts may contract, leading to functional and appearance issues. Conversely, defects treated with full-thickness skin autografts often result in more satisfactory function and appearance. The development of tissue-engineered dermal templates has further expanded the scope of wound repair, providing scar reductive and regenerative properties that have extended their use to reconstructive surgical interventions. Although their interactions with the wound microenvironment are not fully understood, these templates have shown potential in local infection control. This narrative review discusses the current state of wound repair in burn injuries, focusing on the progress made from wound cover to wound closure and local infection control. Advancements in technology and therapies hold promise for improving the outcomes for burn injury patients. Understanding the underlying mechanisms of wound repair and tissue regeneration may provide new insights for developing more effective treatments in the future. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2025 Elektronická adresa https://doi.org/10.1016/j.jss.2023.12.043
Počet záznamů: 1