Počet záznamů: 1
Modelling the role of membrane mechanics in cell adhesion on titanium oxide nanotubes
- 1.
SYSNO ASEP 0583165 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Modelling the role of membrane mechanics in cell adhesion on titanium oxide nanotubes Tvůrce(i) Daniel, M. (CZ)
Filipič, K.E. (CZ)
Filová, Eva (UEM-P) RID, ORCID
Fojt, J. (CZ)Zdroj.dok. Computer methods in biomechanics and biomedical engineering - ISSN 1025-5842
Roč. 26, č. 3 (2023), s. 281-290Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova titanium ; nanotubes ; biomechanics ; adhesion ; surface energy ; cell membrane ; bending Obor OECD Biophysics CEP GA16-14758S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UEM-P - RVO:68378041 UT WOS 000778467000001 EID SCOPUS 85128231530 DOI 10.1080/10255842.2022.2058875 Anotace
Titanium surface treated with titanium oxide nanotubes was used in many studies to quantify the effect of surface topography on cell fate. However, the predicted optimal diameter of nanotubes considerably differs among studies. We propose a model that explains cell adhesion to a nanostructured surface by considering the deformation energy of cell protrusions into titanium nanotubes and the adhesion to the surface. The optimal surface topology is defined as a geometry that gives the membrane a minimum energy shape. A dimensionless parameter, the cell interaction index, was proposed to describe the interplay between the cell membrane bending, the intrinsic curvature, and the strength of cell adhesion. Model simulation shows that an optimal nanotube diameter ranging from 20 nm to 100 nm (cell interaction index between 0.2 and 1, respectively) is feasible within a certain range of parameters describing cell membrane adhesion and bending. The results indicate a possibility to tune the topology of a nanostructural surface in order to enhance the proliferation and differentiation of cells mechanically compatible with the given surface geometry while suppressing the growth of other mechanically incompatible cells.Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2024 Elektronická adresa https://www.tandfonline.com/doi/full/10.1080/10255842.2022.2058875
Počet záznamů: 1