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Tannic acid- and N-acetylcysteine-chitosan-modified magnetic nanoparticles reduce hepatic oxidative stress in prediabetic rats
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SYSNO ASEP 0582515 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Tannic acid- and N-acetylcysteine-chitosan-modified magnetic nanoparticles reduce hepatic oxidative stress in prediabetic rats Tvůrce(i) Swietek, Malgorzata Anna (UMCH-V) RID, ORCID
Marková, I. (CZ)
Malínská, H. (CZ)
Hüttl, M. (CZ)
Miklánková, D. (CZ)
Černá, K. (CZ)
Konefal, Rafal (UMCH-V) RID, ORCID
Horák, Daniel (UMCH-V) RID, ORCIDČíslo článku 113791 Zdroj.dok. Colloids and Surfaces B-Biointerfaces. - : Elsevier - ISSN 0927-7765
Roč. 235, March (2024)Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova magnetic ; nanoparticles ; chitosan, N-acetylcysteine Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP LX22NPO5102 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 001180011900001 EID SCOPUS 85184522235 DOI 10.1016/j.colsurfb.2024.113791 Anotace Magnetic nanoparticles (MNPs) modified with tannic acid (TA) have shown remarkable success as an antioxidant and antimicrobial therapeutic agent. Herein, we report a synthetic procedure for the preparation of silica-coated MNPs modified with N-acetylcysteine-modified chitosan and TA. This was achieved by free-radical grafting of NAC onto chitosan (CS), a layer-by-layer technique for modifying negatively charged MNP@SiO2 nanoparticles with positively charged CS-NAC, and crosslinking CS with TA. The antioxidant and metabolic effects of MNP@SiO2-CS-NAC and MNP@SiO2-CS-NAC-TA nanoparticles were tested in a model of prediabetic rats with hepatic steatosis, the hereditary hypertriglyceridemic rats (HHTg). The particles exhibited significant antioxidant properties in the liver, increasing the activity of the antioxidant enzymes superoxide dismutase (SOD), glutathione reductase (GR) and glutathione peroxidase (GPx), decreasing the concentration of the lipoperoxidation product malondialdehyde (MDA), and improving the antioxidant status determined as the ratio of reduced to oxidized glutathione, in particular, TA increased some antioxidant parameters. MNPs carrying antioxidants such as NAC and TA could thus represent a promising therapeutic agent for the treatment of various diseases accompanied by increased oxidative stress. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2025 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0927776524000493?via%3Dihub
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