Počet záznamů: 1
Biodegradable covalently crosslinked poly[N-(2-hydroxypropyl) methacrylamide] nanogels: preparation and physicochemical properties
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SYSNO ASEP 0581942 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Biodegradable covalently crosslinked poly[N-(2-hydroxypropyl) methacrylamide] nanogels: preparation and physicochemical properties Tvůrce(i) Kousalová, Jana (UMCH-V) RID, ORCID
Šálek, Petr (UMCH-V) RID, ORCID
Pavlova, Ewa (UMCH-V) RID
Konefal, Rafal (UMCH-V) RID, ORCID
Kobera, Libor (UMCH-V) RID, ORCID
Brus, Jiří (UMCH-V) RID, ORCID
Kočková, Olga (UMCH-V) RID, ORCID
Etrych, Tomáš (UMCH-V) RID, ORCIDČíslo článku 263 Zdroj.dok. Polymers. - : MDPI
Roč. 16, č. 2 (2024)Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova biodegradable ; dispersion polymerization ; glutathione Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP LX22NPO5102 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 001153027000001 EID SCOPUS 85183324052 DOI 10.3390/polym16020263 Anotace Recently, suitably sized polymer-based nanogels containing functional groups for the binding of biologically active substances and ultimately degradable to products that can be removed by glomerular filtration have become extensively studied systems in the field of drug delivery. Herein, we designed and tailored the synthesis of hydrophilic and biodegradable poly[N-(2-hydroxypropyl) methacrylamide-co-N,N′-bis(acryloyl) cystamine-co-6-methacrylamidohexanoyl hydrazine] (PHPMA-BAC-BMH) nanogels. The facile and versatile dispersion polymerization enabled the preparation of nanogels with a diameter below 50 nm, which is the key parameter for efficient and selective passive tumor targeting. The effects of the N,N′-bis(acryloyl) cystamine crosslinker, polymerization composition, and medium including H2O/MetCel and H2O/EtCel on the particle size, particle size distribution, morphology, and polymerization kinetics and copolymer composition were investigated in detail. We demonstrated the formation of a 38 nm colloidally stable PHPMA-BAC-BMH nanogel with a core–shell structure that can be rapidly degraded in the presence of 10 mM glutathione solution under physiologic conditions. The nanogels were stable in an aqueous solution modeling the bloodstream, thus, these nanogels have the potential to become highly important carriers in the drug delivery of various molecules. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2025 Elektronická adresa https://www.mdpi.com/2073-4360/16/2/263
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