Počet záznamů: 1
Structure, dynamics, and functional properties of hybrid alginate-pectin gels dually crosslinked by Ca2+ and Zn2+ ions designed as a delivery device for self-emulsifying systems for lipophilic phytotherapeutics
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SYSNO ASEP 0581912 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve SCOPUS Název Structure, dynamics, and functional properties of hybrid alginate-pectin gels dually crosslinked by Ca2+ and Zn2+ ions designed as a delivery device for self-emulsifying systems for lipophilic phytotherapeutics Tvůrce(i) Urbanová, Martina (UMCH-V) RID, ORCID
Macků, Jan (UMCH-V) RID
Kubová, K. (CZ)
Vyslouzil, J. (CZ)
Muselík, J. (CZ)
Šlouf, Miroslav (UMCH-V) RID, ORCID
Šeděnková, Ivana (UMCH-V) RID
Kočková, Olga (UMCH-V) RID, ORCID
Janisova, Larisa (UMCH-V) RID, ORCID
Masek, J. (CZ)
Mašková, E. (CZ)
Novobilský, A. (CZ)
Parenicova, M. (CZ)
Konefal, Rafal (UMCH-V) RID, ORCID
Czernek, Jiří (UMCH-V) RID
Vetchy, D. (CZ)
Pavelková, M. (CZ)
Brus, Jiří (UMCH-V) RID, ORCIDČíslo článku 109693 Zdroj.dok. Food Hydrocolloids. - : Elsevier - ISSN 0268-005X
Roč. 150, May (2024)Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova alginate-pectin gels ; dual crosslinking ; structure Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP GA22-03187S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 EID SCOPUS 85182024378 DOI 10.1016/j.foodhyd.2023.109693 Anotace Alginate gels are outstanding biomaterials widely applicable in food and pharmaceutical industries. This contribution provides comprehensive insight into the design of advanced hybrid alginate/pectin co-networks double crosslinked by Ca2+/Zn2+ ions encapsulating self-emulsifying systems (SES). The tunable mucoadhesive properties, structural stability, integrity, dissolution profiles, and enhanced in-vivo bioavailability make the synthesized hybrid systems ideal vehicles for the delivery of lipophilic phytotherapeutics, allowing the long-term site-specific treatment of intestinal inflammation. This work also provides a thorough understanding of the structure-property relationships of alginate-pectin gels at the atomic resolution level. It was found out that SES molecules form well-distributed, phase-separated microparticles that interact with the polysaccharide matrix through a well-defined interface. The hybrid alginate-pectin gel is highly cross-linked, with both types of polysaccharides participating in the network formation. The observed surface interactions of SES droplets increase the intrinsic mobility of the network. The plasticizing effect can be regulated by the amount of pectin macromolecules, whose interaction with alginate chains enables a strengthening of the polysaccharide network. Overall, the domain-like architecture of hybrid alginate-pectin gels synthesized by external ionic gelation is revealed, the key structural motifs responsible for their properties are discovered, and the pathways allowing their regulation are identified. Biological in-vivo tests then confirmed positive effects of the synthesized systems in living organisms. The strategy presented thus offers a new perspective for the rational design of alginate-based materials for the microencapsulation of bioactive compounds for advanced orally administered delivery systems or controlled-release decontaminators applicable in the food and nutraceutical processing industries. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2025 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0268005X23012390?via%3Dihub
Počet záznamů: 1