Počet záznamů: 1
Comparing species-different responses in pulmonary fibrosis research: Current understanding of in vitro lung cell models and nanomaterials
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SYSNO ASEP 0581653 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Comparing species-different responses in pulmonary fibrosis research: Current understanding of in vitro lung cell models and nanomaterials Tvůrce(i) Keshavan, S. (CH)
Bannuscher, A. (CH)
Drasler, B. (CH)
Barošová, Hana (UEM-P)
Petri-Fink, A. (CH)
Rothen-Rutishauser, B. (CH)Číslo článku 183 Zdroj.dok. European Journal of Pharmaceutical Sciences. - : Elsevier - ISSN 0928-0987
Roč. 183, apr. (2023)Poč.str. 18 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova pulmonary fibrosis ; in vitro lung models ; adverse outcome pathway ; nanomaterials Obor OECD Public and environmental health Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 000927781100001 EID SCOPUS 85147207609 DOI 10.1016/j.ejps.2023.106387 Anotace Pulmonary fibrosis (PF) is a chronic, irreversible lung disease that is typically fatal and characterized by an abnormal fibrotic response. As a result, vast areas of the lungs are gradually affected, and gas exchange is impaired, making it one of the world's leading causes of death. This can be attributed to a lack of understanding of the onset and progression of the disease, as well as a poor understanding of the mechanism of adverse responses to various factors, such as exposure to allergens, nanomaterials, environmental pollutants, etc. So far, the most frequently used preclinical evaluation paradigm for PF is still animal testing. Nonetheless, there is an urgent need to understand the factors that induce PF and find novel therapeutic targets for PF in humans. In this regard, robust and realistic in vitro fibrosis models are required to understand the mechanism of adverse responses. Over the years, several in vitro and ex vivo models have been developed with the goal of mimicking the biological barriers of the lung as closely as possible. This review summarizes recent progress towards the development of experimental models suitable for predicting fibrotic responses, with an emphasis on cell culture methods, nanomaterials, and a comparison of results from studies using cells from various species. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2024 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0928098723000180?via%3Dihub
Počet záznamů: 1