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Retinal venular vessel diameters are smaller during ten days of bed rest
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SYSNO ASEP 0581564 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Retinal venular vessel diameters are smaller during ten days of bed rest Tvůrce(i) Saloň, I. (CZ)
Ciftci, G. M. (DE)
Zubac, D. (DE)
Šimunič, B. (SI)
Pišot, R. (SI)
Narici, M. (IT)
Fredriksen, P. M. (NO)
Nkeh-Chungag, B. N. (ZA)
Sourij, H. (AT)
Šerý, Omar (UZFG-Y) RID
Schmid-Zalaudek, K. (AT)
Steuber, B. (AT)
De Boever, P. (BE)
Goswami, N. (AT)Celkový počet autorů 14 Číslo článku 19258 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 13, č. 1 (2023)Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova baroreflex control ; plasma-volume ; blood-flow ; risk ; microgravity ; hypertension ; responses ; atrophy Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Cardiac and Cardiovascular systems Způsob publikování Open access Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 001101369900008 EID SCOPUS 85175995900 DOI 10.1038/s41598-023-46177-x Anotace Older individuals experience cardiovascular dysfunction during extended bedridden hospital or care home stays. Bed rest is also used as a model to simulate accelerated vascular deconditioning occurring during spaceflight. This study investigates changes in retinal microcirculation during a ten-day bed rest protocol. Ten healthy young males (22.9 +/- 4.7 years, body mass index: 23.6 +/- 2.5 kg center dot m-2) participated in a strictly controlled repeated-measures bed rest study lasting ten days. High-resolution images were obtained using a hand-held fundus camera at baseline, daily during the 10 days of bed rest, and 1 day after re-ambulation. Retinal vessel analysis was performed using a semi-automated software system to obtain metrics for retinal arteriolar and venular diameters, central retinal artery equivalent and central retinal vein equivalent, respectively. Data analysis employed a mixed linear model. At the end of the bed rest period, a significant decrease in retinal venular diameter was observed, indicated by a significantly lower central retinal vein equivalent (from 226.1 mu m, CI 8.90, to 211.4 mu m, CI 8.28, p = .026), while no significant changes in central retinal artery equivalent were noted. Prolonged bed rest confinement resulted in a significant (up to 6.5%) reduction in retinal venular diameter. These findings suggest that the changes in retinal venular diameter during bedrest may be attributed to plasma volume losses and reflect overall (cardio)-vascular deconditioning. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2024 Elektronická adresa https://www.nature.com/articles/s41598-023-46177-x
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