Počet záznamů: 1
Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract
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SYSNO ASEP 0580525 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract Tvůrce(i) Oral, C.M.M. (CZ)
Ussia, M. (CZ)
Urso, M. (CZ)
Salát, Jiří (BC-A) RID, ORCID
Novobilský, A. (CZ)
Štefánik, M. (CZ)
Růžek, Daniel (BC-A) RID, ORCID
Pumera, M. (CZ)Celkový počet autorů 8 Číslo článku 2202682 Zdroj.dok. Advanced Healthcare Materials. - : Wiley - ISSN 2192-2640
Roč. 12, MAR (2022)Poč.str. 9 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova nanoparticles ; computed tomography ; gastrointestinal tract ; magnetic actuation ; medical imaging ; nanomotors ; nanoswimmers ; tracking Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology Způsob publikování Omezený přístup Institucionální podpora BC-A - RVO:60077344 UT WOS 000903078100001 EID SCOPUS 85145028340 DOI 10.1002/adhm.202202682 Anotace Magnetic nanorobots offer wireless navigation capability in hard-to-reach areas of the human body for targeted therapy and diagnosis. Though in vivo imaging is required for guidance of the magnetic nanorobots toward the target areas, most of the imaging techniques are inadequate to reveal the potential locomotion routes. This work proposes the use of radiopaque magnetic nanorobots along with microcomputed tomography (microCT) for localized in vivo imaging applications. The nanorobots consist of a contrast agent, barium sulfate (BaSO4), magnetized by the decoration of magnetite (Fe3O4) particles. The magnetic features lead to actuation under rotating magnetic fields and enable precise navigation in a microfluidic channel used to simulate confined spaces of the body. In this channel, the intrinsic radiopacity of the nanorobots also provides the possibility to reveal the internal structures by X-ray contrast. Furthermore, in vitro analysis indicates nontoxicity of the nanorobots. In vivo experiments demonstrate localization of the nanorobots in a specific part of the gastrointestinal (GI) tract upon the influence of the magnetic field, indicating the efficient control even in the presence of natural peristaltic movements. The nanorobots reported here highlight that smart nanorobotic contrast agents can improve the current imaging-based diagnosis techniques by providing untethered controllability in vivo. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2024 Elektronická adresa https://onlinelibrary.wiley.com/doi/10.1002/adhm.202202682
Počet záznamů: 1