Počet záznamů: 1
Effects of antimicrobial metal nanoparticles on characteristics and function properties of mouse mesenchymal stem cells
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SYSNO ASEP 0580369 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Effects of antimicrobial metal nanoparticles on characteristics and function properties of mouse mesenchymal stem cells Tvůrce(i) Echalar, Barbora (UEM-P)
Dostálová, Dominika (UEM-P)
Palacká, Kateřina (UEM-P) ORCID
Javorková, Eliška (UEM-P) RID
Heřmánková, Barbora (UEM-P) RID, ORCID
Červená, Tereza (UEM-P) ORCID, RID
Zajícová, Alena (UEM-P) RID
Holáň, Vladimír (UEM-P) RID
Rössner ml., Pavel (UEM-P) RID, ORCIDČíslo článku 105536 Zdroj.dok. Toxicology in Vitro. - : Elsevier - ISSN 0887-2333
Roč. 87, mar (2023)Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova metal nanoparticles ; mesenchymal stem cells ; dose-dependent toxicity ; gene expression ; cytokine production Obor OECD Cell biology CEP GA21-17720S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 000910075000001 EID SCOPUS 85144298955 DOI 10.1016/j.tiv.2022.105536 Anotace Nanoparticles (NPs) have a wide use in various field of industry and in medicine, where they represent a promise for their antimicrobial effects. Simultaneous application of NPs and therapeutic stem cells can speed up tissue regeneration and improve healing process but there is a danger of negative impacts of NPs on stem cells. Therefore, we tested effects of four types of metal antimicrobial NPs on characteristics and function properties of mouse mesenchymal stem cells (MSCs) in vitro. All types of tested NPs, i.e. zinc oxide, silver, copper oxide and titanium dioxide, exerted negative effects on the expression of phenotypic markers, metabolic activity, differ-entiation potential, expression of genes for immunoregulatory molecules and on production of cytokines and growth factors by MSCs. However, there were apparent differences in the impact of individual types of NPs on tested characteristics and function properties of MSCs. The results showed that individual types of NPs influence the activity of MSCs, and thus the use of metal NPs during tissue regeneration and in combination with stem cell therapy should be well considered. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2024 Elektronická adresa https://www.sciencedirect.com/science/article/abs/pii/S088723332200234X?via%3Dihub
Počet záznamů: 1