Počet záznamů: 1
Biological Auto(chemi)luminescence Imaging of Oxidative Processes in Human Skin
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SYSNO ASEP 0577023 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Biological Auto(chemi)luminescence Imaging of Oxidative Processes in Human Skin Tvůrce(i) Poplová, Michaela (URE-Y)
Prasad, A. (IN)
van Wijk, E.P.A. (NL)
Pospíšil, P. (CZ)
Cifra, Michal (URE-Y) RID, ORCID, SAICelkový počet autorů 5 Zdroj.dok. Analytical Chemistry. - : American Chemical Society - ISSN 0003-2700
Roč. 95, č. 40 (2023), s. 14853-14860Poč.str. 8 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Luminescence ; Stress-induced ; Oxidative stress Vědní obor RIV BH - Optika, masery a lasery Obor OECD Optics (including laser optics and quantum optics) CEP GX20-06873X GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora URE-Y - RVO:67985882 UT WOS 001077073000001 EID SCOPUS 85174818928 DOI 10.1021/acs.analchem.3c01566 Anotace Oxidative processes in all types of organisms cause the chemical formation of electronically excited species, with subsequent ultraweak photon emission termed biological auto(chemi)luminescence (BAL). Imaging this luminescence phenomenon using ultrasensitive devices could potentially enable monitoring of oxidative stress in optically accessible areas of the human body, such as skin. Although oxidative stress induced by UV light has been explored, for chemically induced stress, there is no in vivo-quantified imaging of oxidative processes in human skin using BAL under the controlled extent of oxidative stress conditions. Furthermore, the mechanisms and dynamics of BAL from the skin have not been fully explored. Here, we demonstrate that different degrees of chemically induced oxidative stress on the skin can be spatially resolved quantitatively through noninvasive label-free BAL imaging. Additionally, to gain insight into the underlying mechanisms, a minimal chemical model of skin based on a mixture of lipid, melanin, and water was developed and used to show that it can be used to reproduce essential features of the response of real skin to oxidative stress. Our results contribute to novel, noninvasive photonic label-free methods for quantitative sensing of oxidative processes and oxidative stress. Pracoviště Ústav fotoniky a elektroniky Kontakt Petr Vacek, vacek@ufe.cz, Tel.: 266 773 413, 266 773 438, 266 773 488 Rok sběru 2024 Elektronická adresa DOI10.1021/acs.analchem.3c01566
Počet záznamů: 1