Počet záznamů: 1
Polysaccharide BAP1 of Bifidobacterium adolescentis CCDM 368 is a biologically active molecule with immunomodulatory properties
- 1.
SYSNO ASEP 0576316 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Polysaccharide BAP1 of Bifidobacterium adolescentis CCDM 368 is a biologically active molecule with immunomodulatory properties Tvůrce(i) Pacyga-Prus, K. (PL)
Jakubczyk, D. (PL)
Sandström, C. (SE)
Šrůtková, Dagmar (MBU-M) ORCID, RID
Pyclik, M. J. (PL)
Leszczynska, K. (PL)
Ciekot, J. (PL)
Razim, A. (PL)
Schwarzer, Martin (MBU-M) ORCID, RID
Górska, S. (PL)Číslo článku 120980 Zdroj.dok. Carbohydrate Polymers. - : Elsevier - ISSN 0144-8617
Roč. 315, 1 September 2023 (2023)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Allergy ; Bifidobacterium ; Polysaccharides ; Surface antigens ; Macromolecules Obor OECD Polymer science CEP GF23-04050L GA ČR - Grantová agentura ČR 8JPL19046 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 001008562200001 EID SCOPUS 85159180885 DOI 10.1016/j.carbpol.2023.120980 Anotace Bifidobacteria are among the most common bacteria used for their probiotic properties and their impact on the maturation and function of the immune system has been well-described. Recently, scientific interest is shifting from live bacteria to defined bacteria-derived biologically active molecules. Their greatest advantage over probiotics is the defined structure and the effect independent of the viability status of the bacteria. Here, we aim to characterize Bifidobacterium adolescentis CCDM 368 surface antigens that include polysaccharides (PSs), lip-oteichoic acids (LTAs), and peptidoglycan (PG). Among them, Bad368.1 PS was observed to modulate OVA-induced cytokine production in cells isolated from OVA-sensitized mice by increasing the production of Th1-related IFN-gamma and inhibition of Th2-related IL-5 and IL-13 cytokines (in vitro). Moreover, Bad368.1 PS (BAP1) is efficiently engulfed and transferred between epithelial and dendritic cells. Therefore, we propose that the Bad368.1 PS (BAP1) can be used for the modulation of allergic diseases in humans. Structural studies revealed that Bad368.1 PS has an average molecular mass of approximately 9,99 x 106 Da and it consists of glucose, galactose, and rhamnose residues that are creating the following repeating unit: [-> 2)-beta-D-Glcp-(1> 3)-beta-L-Rhap-(1> 4)-beta-D-Glcp-(1> 3)-alpha-L-Rhap-(1> 4)-beta-D-Glcp-(1> 3)-alpha-D-Galp-(1> ]n Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2024 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0144861723004459?pes=vor
Počet záznamů: 1