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Synthesis and anti-fouling properties of zwitterionic poly(L-glutamic acid)
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SYSNO ASEP 0573142 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Synthesis and anti-fouling properties of zwitterionic poly(L-glutamic acid) Tvůrce(i) Hladysh, Sviatoslav (UMCH-V) RID, ORCID
Dvořáková, Jana (UMCH-V) RID, ORCID
Proks, Vladimír (UMCH-V) RID, ORCIDZdroj.dok. Macromolecular Research - ISSN 1598-5032
Roč. 31, č. 6 (2023), s. 593-601Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. KR - Korejská republika Klíč. slova zwitterionic polymer ; poly(L-glutamic acid) ; anti-fouling Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP GA21-06524S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000944096700001 EID SCOPUS 85149290139 DOI 10.1007/s13233-023-00145-6 Anotace Zwitterionic polymers are frequently used as non-fouling materials for surface modification with following application in medical devices, implants or areas of our lives such as food, water, and energy. Here, authors report the synthesis of zwitterionic poly(l-glutamic acid) copolymer bearing sulfobetaine via combining the ring-opening polymerization of N-carboxyanhydride of γ-benzyl-l-glutamate and grafting reaction of propargylamine, tyramine, and 3-(dimethylamino)-1-propylamine to the polymer backbone with subsequent reaction of 1,3-propanesultone leading to the formation of zwitterionic poly(l-glutamic acid) containing sulfobetaine groups. Zwitterionic properties of the copolymer are represented by positively charged quaternary ammonium groups and negatively charged sulfobetaine moieties. The chemical structure of the synthesized zwitterionic poly(l-glutamic acid) was characterized by 1H NMR, FTIR, and UV/Vis spectroscopy. The zwitterionic abilities of copolymer were confirmed by zeta potential measurements. The zeta potential of zwitterionic polymer decreased from + 15 mV to − 19 mV upon stepwise pH increases from 2 to 11. The surface properties such as hydrophilicity and non-fouling abilities were tested by contact angle analysis and surface plasmon resonance technique, respectively. The prepared material indicates the formation of highly hydrophilic surfaces with relatively low contact angle (26°) and remarkable anti-protein adsorption functions reflected in lower resonance wavelength shifts from SPR sensogram. Results of this work show the importance of the developed biodegradable zwitterionic poly(l-glutamic acid)-based coatings for applications in various biomedical fields. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2024 Elektronická adresa https://link.springer.com/article/10.1007/s13233-023-00145-6
Počet záznamů: 1