Počet záznamů: 1
4-Methylumbeliferone Treatment at a Dose of 1.2 g/kg/Day Is Safe for Long-Term Usage in Rats
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SYSNO ASEP 0572030 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název 4-Methylumbeliferone Treatment at a Dose of 1.2 g/kg/Day Is Safe for Long-Term Usage in Rats Tvůrce(i) Štěpánková, Kateřina (UEM-P) ORCID
Mareková, Dana (UEM-P)
Kubášová, K. (CZ)
Sedláček, R. (CZ)
Turnovcová, Karolína (UEM-P) ORCID
Vacková, Irena (UEM-P)
Kubinová, Šárka (UEM-P) RID, ORCID
Makovický, P. (SK)
Petrovičová, M. (CZ)
Kwok, Jessica (UEM-P) ORCID, RID
Jendelová, Pavla (UEM-P) RID, ORCID
Machová-Urdzíková, Lucia (UEM-P) ORCIDČíslo článku 3799 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 24, č. 4 (2023)Poč.str. 23 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova hyaluronan ; 4-methylumbelliferone ; chondroitin sulphates ; neuroplasticity Obor OECD Toxicology CEP EF15_003/0000419 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA19-10365S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 000945189900001 EID SCOPUS 85149002553 DOI 10.3390/ijms24043799 Anotace 4-methylumbelliferone (4MU) has been suggested as a potential therapeutic agent for a wide range of neurological diseases. The current study aimed to evaluate the physiological changes and potential side effects after 10 weeks of 4MU treatment at a dose of 1.2 g/kg/day in healthy rats, and after 2 months of a wash-out period. Our findings revealed downregulation of hyaluronan (HA) and chondroitin sulphate proteoglycans throughout the body, significantly increased bile acids in blood samples in weeks 4 and 7 of the 4MU treatment, as well as increased blood sugars and proteins a few weeks after 4MU administration, and significantly increased interleukins IL10, IL12p70 and IFN gamma after 10 weeks of 4MU treatment. These effects, however, were reversed and no significant difference was observed between control treated and 4MU-treated animals after a 9-week wash-out period. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2024 Elektronická adresa https://www.mdpi.com/1422-0067/24/4/3799
Počet záznamů: 1