Počet záznamů: 1
Toward building mass spectrometry-based metabolomics and lipidomics atlases for biological and clinical research
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SYSNO ASEP 0570367 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Toward building mass spectrometry-based metabolomics and lipidomics atlases for biological and clinical research Tvůrce(i) Rakušanová, Stanislava (FGU-C) ORCID
Fiehn, O. (US)
Čajka, Tomáš (FGU-C) RID, ORCID, SAIČíslo článku 116825 Zdroj.dok. TrAC-Trends in Analytical Chemistry. - : Elsevier - ISSN 0165-9936
Roč. 158, January (2023)Poč.str. 21 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova metabolomics ; lipidomics ; analytical methods ; mass spectrometry ; atlas ; database Obor OECD Analytical chemistry CEP NU20-01-00186 GA MZd - Ministerstvo zdravotnictví NU22-02-00161 GA MZd - Ministerstvo zdravotnictví LX22NPO5104 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LTAUSA19124 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA20-21114S GA ČR - Grantová agentura ČR GA21-00477S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000995351600001 EID SCOPUS 85142678094 DOI 10.1016/j.trac.2022.116825 Anotace Current metabolomics and lipidomics studies are limited in the number of examined matrices, the breadth and scope of methods, reporting the number of metabolites, and data sharing. Here, we discuss the concept of metabolomics and lipidomics atlases that characterize the quantitative distribution and relationships of metabolites in biological matrices and serve as a resource for future studies. Combined sample extraction is recommended to screen the metabolome and lipidome comprehensively. A multiplatform mass spectrometry-based approach with methods for each fraction should follow to separate and detect metabolites differing in their physicochemical properties. Since many known metabolites are detected through untargeted analysis, routine use of multiple internal standards for quantification is advised. This approach provides semiquantitative data and delivers molar concentrations for selected polar metabolites and lipids. An interactive web tool to query metabolites, generate statistical models, visualize data, and download the results should be developed to access generated data easily. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2024 Elektronická adresa https://doi.org/10.1016/j.trac.2022.116825
Počet záznamů: 1