Počet záznamů: 1

Evaluation of blood-brain barrier integrity by the analysis of dynamic contrast-enhanced MRI – a comparison of quantitative and semi-quantitative methods.

SYSNO ASEP	0567451
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Evaluation of blood-brain barrier integrity by the analysis of dynamic contrast-enhanced MRI – a comparison of quantitative and semi-quantitative methods.
Tvůrce(i)	Kala, David (FGU-C) Šulc, V. (CZ) Olšerová, A. (CZ) Svoboda, Jan (FGU-C) Prysiazhniuk, Yeva (FGU-C)_ORCID Pošusta, Antonín (FGU-C)_RID Kynčl, M. (CZ) Šanda, J. (CZ) Tomek, A. (CZ) Otáhal, Jakub (FGU-C)_{RID, ORCID, SAI}
Zdroj.dok.	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 71, Suppl. 2 (2022), S259-s275
Poč.str.	17 s.
Jazyk dok.	eng - angličtina
Země vyd.	CZ - Česká republika
Klíč. slova	DCE MRI ; time-intensity curve ; blood-brain barrier ; stroke ; Toft’s model
Obor OECD	Neurosciences (including psychophysiology
CEP	NU21-08-00228 GA MZd - Ministerstvo zdravotnictví
	LM2018129 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	LX22NPO5107 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Výzkumná infrastruktura	Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i.
Způsob publikování	Open access
Institucionální podpora	FGU-C - RVO:67985823
UT WOS	000924861700011
EID SCOPUS	85146336279
DOI	10.33549/physiolres.934998
Anotace	Disruption of the blood-brain barrier (BBB) is a key feature of various brain disorders. To assess its integrity a parametrization of dynamic magnetic resonance imaging (DCE MRI) with a contrast agent (CA) is broadly used. Parametrization can be done quantitatively or semi-quantitatively. Quantitative methods directly describe BBB permeability but exhibit several drawbacks such as high computation demands, reproducibility issues, or low robustness. Semi-quantitative methods are fast to compute, simply mathematically described, and robust, however, they do not describe the status of BBB directly but only as a variation of CA concentration in measured tissue. Our goal was to elucidate differences between five semi-quantitative parameters: maximal intensity (Imax), normalized permeability index (NPI), and difference in DCE values between three timepoints: baseline, 5 min, and 15 min (delta5-0, delta15-0, delta15-5) and two quantitative parameters: transfer constant (Ktrans) and an extravascular fraction (Ve). For the purpose of comparison, we analyzed DCE data of four patients 12-15 days after the stroke with visible CA enhancement. Calculated parameters showed abnormalities spatially corresponding with the ischemic lesion, however, findings in individual parameters morphometrically differed. Ktrans and Ve were highly correlated. Delta5-0 and delta15-0 were prominent in regions with rapid CA enhancement and highly correlated with Ktrans. Abnormalities in delta15-5 and NPI were more homogenous with less variable values, smoother borders, and less detail than Ktrans. Moreover, only delta15-5 and NPI were able to distinguish vessels from extravascular space. Our comparison provides important knowledge for understanding and interpreting parameters derived from DCE MRI by both quantitative and semi-quantitative methods.
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2023
Elektronická adresa	https://www.biomed.cas.cz/physiolres/pdf/2022/71_S259.pdf

Počet záznamů: 1