Počet záznamů: 1
Recent advances in deciphering oligodendrocyte heterogeneity with single-cell transcriptomics
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SYSNO ASEP 0566908 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Recent advances in deciphering oligodendrocyte heterogeneity with single-cell transcriptomics Tvůrce(i) Valihrach, Lukáš (UEM-P)
Matúšová, Z. (CZ)
Žucha, D. (CZ)
Klassen, R. (CZ)
Benešová, Š. (CZ)
Abaffy, P. (CZ)
Kubista, M. (CZ)
Anděrová, Miroslava (UEM-P) RID, ORCIDČíslo článku 1025012 Zdroj.dok. Frontiers in Cellular Neuroscience. - : Frontiers Media
Roč. 16, oct. (2022)Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova oligodendrocyte ; heterogeneity ; scRNA-seq ; snRNA-seq ; populations ; marker genes Obor OECD Neurosciences (including psychophysiology CEP LX22NPO5107 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 000875842100001 EID SCOPUS 85140777633 DOI 10.3389/fncel.2022.1025012 Anotace Oligodendrocytes (OL) have been for decades considered a passive, homogenous population of cells that provide support to neurons, and show a limited response to pathological stimuli. This view has been dramatically changed by the introduction of powerful transcriptomic methods that have uncovered a broad spectrum of OL populations that co-exist within the healthy central nervous system (CNS) and also across a variety of diseases. Specifically, single-cell and single-nucleus RNA-sequencing (scRNA-seq, snRNA-seq) have been used to reveal OL variations in maturation, myelination and immune status. The newly discovered immunomodulatory role suggests that OL may serve as targets for future therapies. In this review, we summarize the current understanding of OL heterogeneity in mammalian CNS as revealed by scRNA-seq and snRNA-seq. We provide a list of key studies that identify consensus marker genes defining the currently known OL populations. This resource can be used to standardize analysis of OL related datasets and improve their interpretation, ultimately leading to a better understanding of OL functions in health and disease. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2023 Elektronická adresa https://www.frontiersin.org/articles/10.3389/fncel.2022.1025012/full
Počet záznamů: 1