Počet záznamů: 1
Ion transfer voltammetric and LC/MS investigations of the oxidative degradation process of fentanyl and some of its structural analogs
- 1.
SYSNO ASEP 0566842 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Ion transfer voltammetric and LC/MS investigations of the oxidative degradation process of fentanyl and some of its structural analogs Tvůrce(i) Langmaier, Jan (UFCH-W) RID, ORCID, SAI
Skopalová, J. (CZ)
Zajacová Cechová, M. (CZ)
Kahánková, T. (CZ)
Jerga, R. (CZ)
Barták, P. (CZ)
Samec, Zdeněk (UFCH-W) RID, ORCID
Navrátil, Tomáš (UFCH-W) RID, ORCIDČíslo článku 141848 Zdroj.dok. Electrochimica acta. - : Elsevier - ISSN 0013-4686
Roč. 441, FEB 2023 (2023)Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Fentanyl ; HO• radicals ; Catalytic degradation ; Ion transfer voltammetry Vědní obor RIV CF - Fyzikální chemie a teoretická chemie Obor OECD Physical chemistry CEP GA20-07350S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UFCH-W - RVO:61388955 UT WOS 000923075900001 EID SCOPUS 85146048518 DOI 10.1016/j.electacta.2023.141848 Anotace Ion transfer voltammetry at a polarized ionic liquid membrane and LC/MS technique were used to investigate the oxidative time-resolved degradation of the frequently (mis)used opioid fentanyl and some of its structural analogs.
The degradation is based on the reaction of opioids with hydroxyl radicals produced by the catalytic decomposition of hydrogen peroxide. Using the voltammetric technique, it was confirmed that the presence of Fe2+ions and hydrogen peroxide is essential in the degradation process of fentanyl(s). An increasing concentration of ferrous ions accelerates the described reactions, while the reaction rate is much less affected by the concentration of fentanyl.
In an excess of ferrous ions, the course of the reaction can be approximated by a pseudo-first-order reaction with a half-time of 3.85 min. The generation of HO• radicals was proved to be the rate-determining step. Oxidative degradation processes of all investigated fentanyl-related drugs exhibit similar kinetics. A wide variety of fentanyl degradation products were detected and characterized using LC/MS analysis. Mono-, di- and trihydroxylated derivatives in several isomeric forms were observed most abundantly in a relatively short reaction time (5–30 min). The formation of norfentanyl has also been demonstrated.Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2024 Elektronická adresa https://hdl.handle.net/11104/0338116
Počet záznamů: 1