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Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells
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SYSNO ASEP 0566824 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells Tvůrce(i) Lirussi, F. (FR)
Pyrshev, K. (FR)
Yesylevskyy, Semen (UOCHB-X) ORCID
Rivel, T. (FR)
Lopez, T. (FR)
Coppens, E. (FR)
Mura, S. (FR)
Couvreur, P. (FR)
Ramseyer, C. (FR)Číslo článku 166614 Zdroj.dok. Biochimica Et Biophysica Acta-Molecular Basis of Disease. - : Elsevier - ISSN 0925-4439
Roč. 1869, č. 2 (2023)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova gemcitabine-squalene ; nanomedicine ; lipid composition ; selective delivery ; plasma membrane ; cancer targeting Obor OECD Physical chemistry Způsob publikování Omezený přístup Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000931900400007 EID SCOPUS 85144589206 DOI 10.1016/j.bbadis.2022.166614 Anotace Up to now the lipid bilayers were rarely considered as targets in cancer therapy despite pronounced differences in lipid composition between plasma membranes of benign and malignant cells. In this study we demonstrate that the lipid bilayer of the plasma membrane is druggable and suitable for facilitating selective delivery of amphiphilic gemcitabine-squalene nanomedicines to cancer cells. Data from radioactive assays, fluorescent membrane probes and molecular dynamics simulations provide evidence of selective accumulation of gemcitabine-squalene in the plasma membranes with disrupted lipid asymmetry and its subsequent preferential uptake by malignant cells. This causes pronounced cytotoxicity on cancer cells in comparison to their benign counterparts originating from the same tissue. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Rok sběru 2024 Elektronická adresa https://doi.org/10.1016/j.bbadis.2022.166614
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