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Thermoresponsive triblock copolymers as widely applicable 19F magnetic resonance imaging tracers
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SYSNO ASEP 0565996 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Thermoresponsive triblock copolymers as widely applicable 19F magnetic resonance imaging tracers Tvůrce(i) Kolouchová, K. (BE)
Groborz, Ondřej (UMCH-V) ORCID, RID
Šlouf, Miroslav (UMCH-V) RID, ORCID
Herynek, V. (CZ)
Parmentier, L. (BE)
Babuka, David (UMCH-V)
Černochová, Zulfiya (UMCH-V) RID, ORCID
Koucký, F. (CZ)
Sedláček, O. (CZ)
Hrubý, Martin (UMCH-V) RID, ORCID
Hoogenboom, R. (BE)
van Vlierberghe, S. (BE)Zdroj.dok. Chemistry of Materials. - : American Chemical Society - ISSN 0897-4756
Roč. 34, č. 24 (2022), s. 10902-10916Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova physically crosslinked hydrogels ; BAB block copolymers ; fluorine-19 magnetic resonance imaging Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP TO01000074 GA TA ČR - Technologická agentura ČR Výzkumná infrastruktura Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i. Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000906402700001 EID SCOPUS 85143978635 DOI 10.1021/acs.chemmater.2c02589 Anotace Fluorine-19 magnetic resonance imaging (19F MRI) has emerged as a promising noninvasive diagnostic tool, broadening the diagnostic possibilities of commonly used proton MRI. Despite the potential of 19F MRI, an ideal tracer paving the way toward the entry of this method into common medical practice is yet to be developed. In this study, we report on a series of polymeric systems based on thermoresponsive poly[N-(2,2-difluoroethyl)acrylamide] (PDFEA), a polymer considered to be an ideal tracer for 19F MRI. The described systems are designed as BAB triblock copolymers, where B corresponds to thermoresponsive PDFEA blocks and A is a hydrophilic poly(ethylene glycol) block. These BAB triblock copolymers are able to form nanoparticles in dilute aqueous solutions, which undergo a transition into physically cross-linked hydrogels upon increasing the polymer concentration. Since thermoresponsive particle- and hydrogel-based systems are applicable in a wide range of biomedical applications, we created a diagnostic system with potential therapeutic properties (theranostic) as a widely tunable platform through straightforward synthesis while serving a multitude of applications. We analyzed the effect of the BAB block ratio on the self-assembly, thermoresponsiveness, and mechanical properties of the studied hydrogels, together with their suitability for 19F MRI. Finally, their biocompatibility was assessed on a relevant cell line. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2023 Elektronická adresa https://pubs.acs.org/doi/10.1021/acs.chemmater.2c02589
Počet záznamů: 1