Počet záznamů: 1
Surface modifications of a silicalite film designed for coating orthopaedic implants
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SYSNO ASEP 0565677 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Surface modifications of a silicalite film designed for coating orthopaedic implants Tvůrce(i) Brož, Antonín (FGU-C) RID, ORCID, SAI
Jirka, Ivan (UFCH-W) RID, ORCID
Matějka, Roman (FGU-C) RID, ORCID, SAI
Štěpanovská, Jana (FGU-C) ORCID, RID
Doubková, Martina (FGU-C) ORCID, RID
Sajdl, P. (CZ)
Drahokoupil, Jan (FZU-D) RID, ORCID
Volochanskyi, Oleksandr (UFCH-W) ORCID, SAI
Futóová, Terézia (FGU-C)
Bačáková, Lucie (FGU-C) RID, ORCIDČíslo článku 111373 Zdroj.dok. Materials and Design. - : Elsevier - ISSN 0264-1275
Roč. 224, Dec (2022)Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova silicalite ; synthesis ; biocompatibility ; surface modification ; cell differentiation ; implants Obor OECD Biomaterials (as related to medical implants, devices, sensors) CEP GA19-02891S GA ČR - Grantová agentura ČR LM2018124 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 ; UFCH-W - RVO:61388955 ; FZU-D - RVO:68378271 UT WOS 000891761700003 EID SCOPUS 85142184888 DOI 10.1016/j.matdes.2022.111373 Anotace The effect of various surface modifications of silicalite-1 film grown on a Ti6Al4V alloy on biocompatibility and cell differentiation has been addressed. The as-synthesized silicalite film was first modified by alkaline etching and by subsequent treatments in oxygen radiofrequency (O2 RF) plasma, by calcination at 500 °C, and by processing the calcinated samples in the O2 RF plasma. The chemical composition, crystallinity, topography and wettability of samples were characterized using angle-resolved X-ray photoelectron spectroscopy, X-ray diffraction, scanning electron microscopy, and sessile water drop contact angle measurements. We have discovered the presence of a non-zeolitic defective SiOx phase (NZP) with coordinated hydrocarbon chains. The NZP can be removed by the exposition to the O2 RF plasma. The metabolic activity tests done on human osteoblast line Saos-2 revealed that the NZP can influence cell proliferation, however, all studied modifications of silicalite film can be considered biocompatible. The osteogenic differentiation was studied on human mesenchymal stem cells under static conditions and under dynamic (pulsatile and shear) stress. The results obtained by the real-time qPCR and immunofluorescence microscopy suggest that etched, plasma-treated and calcinated + plasma-treated samples are the most promising for osteogenic cell differentiation. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://doi.org/10.1016/j.matdes.2022.111373
Počet záznamů: 1