Počet záznamů: 1
Laterality in functional and metabolic state of the bulbectomised rat brain detected by ASL and 1H MRS: A pilot study
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SYSNO ASEP 0565353 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Laterality in functional and metabolic state of the bulbectomised rat brain detected by ASL and 1H MRS: A pilot study Tvůrce(i) Pavlova, Iveta (UPT-D) RID, SAI, ORCID
Dražanová, Eva (UPT-D) RID, ORCID, SAI
Krátká, Lucie (UPT-D) RID, ORCID, SAI
Amchová, P. (CZ)
Macíček, Ondřej (UPT-D) RID, ORCID, SAI
Starčuková, Jana (UPT-D) RID, SAI, ORCID
Starčuk jr., Zenon (UPT-D) RID, ORCID, SAI
Rudá-Kučerová, J. (CZ)Celkový počet autorů 8 Zdroj.dok. World Journal of Biological Psychiatry - ISSN 1562-2975
Roč. 24, č. 5 (2023), s. 414-428Poč.str. 15 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Arterial spin labelling ; depression ; magnetic resonance spectroscopy ; olfactory bulbectomy ; rats Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemistry and molecular biology CEP EF18_046/0016045 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora UPT-D - RVO:68081731 UT WOS 000861426500001 EID SCOPUS 85141045649 DOI 10.1080/15622975.2022.2124450 Anotace Objectives Pilot study validating the animal model of depression the bilateral olfactory bulbectomy in rats by two nuclear magnetic resonance methods, indirectly detecting the metabolic state of the brain. Furthermore, the study focussed on potential differences in brain laterality. Methods Arterial spin labelling assessed cerebral brain flow in prefrontal, sensorimotor, and piriform cortices, nucleus accumbens, hippocampus, thalamus, circle of Willis, and whole brain. Proton magnetic resonance spectroscopy provided information about relative metabolite concentrations in the cortex and hippocampus. Results Arterial spin labelling found no differences in cerebral perfusion in the group comparison but revealed lateralisation in the thalamus of the control group and the sensorimotor cortex of the bulbectomized rats. Lower Cho/tCr and Cho/NAA levels were found in the right hippocampus in bulbectomized rats. The differences in lateralisation were shown in the hippocampus: mI/tCr in the control group, Cho/NAA, NAA/tCr, Tau/tCr in the model group, and in the cortex: NAA/tCr, mI/tCr in the control group. Conclusion Olfactory bulbectomy affects the neuronal and biochemical profile of the rat brain laterally and, as a model of depression, was validated by two nuclear magnetic resonance methods. Pracoviště Ústav přístrojové techniky Kontakt Martina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178 Rok sběru 2024 Elektronická adresa https://www.tandfonline.com/doi/full/10.1080/15622975.2022.2124450
Počet záznamů: 1