Počet záznamů: 1
Influence of hydrophobic side-chain length in amphiphilic gradient copoly(2-oxazoline)s on the therapeutics loading, stability, cellular uptake and pharmacokinetics of nano-formulation with curcumin
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SYSNO ASEP 0564413 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Influence of hydrophobic side-chain length in amphiphilic gradient copoly(2-oxazoline)s on the therapeutics loading, stability, cellular uptake and pharmacokinetics of nano-formulation with curcumin Tvůrce(i) Datta, S. (SK)
Huntošová, V. (SK)
Jutková, A. (SK)
Seliga, R. (SK)
Kronek, J. (SK)
Tomkova, A. (SK)
Lenkavská, L. (SK)
Máčajová, M. (SK)
Bilčík, B. (SK)
Kundeková, B. (SK)
Čavarga, I. (SK)
Pavlova, Ewa (UMCH-V) RID
Šlouf, Miroslav (UMCH-V) RID, ORCID
Miškovský, P. (SK)
Jančura, D. (SK)Číslo článku 2576 Zdroj.dok. Pharmaceutics. - : MDPI
Roč. 14, č. 12 (2022)Poč.str. 22 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova polymeric nanoparticles ; hydrophobicity ; curcumin Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000936290000001 EID SCOPUS 85144857732 DOI 10.3390/pharmaceutics14122576 Anotace Due to the simple one-step preparation method and a promising application in biomedical research, amphiphilic gradient copoly(2-oxazoline)s are gaining more and more interest compared to their analogous block copolymers. In this work, the curcumin solubilization ability was tested for a series of amphiphilic gradient copoly(2-oxazoline)s with different lengths of hydrophobic side-chains, consisting of 2-ethyl-2-oxazoline as a hydrophilic monomer and 2-(4-alkyloxyphenyl)-2-oxazoline as a hydrophobic monomer. It is shown that the length of the hydrophobic side-chain in the copolymers plays a crucial role in the loading of curcumin onto the self-assembled nanoparticles. The kinetic stability of self-assembled nanoparticles studied using FRET shows a link between their integrity and cellular uptake in human glioblastoma cells. The present study demonstrates how minor changes in the molecular structure of gradient copoly(2-oxazoline)s can lead to significant differences in the loading, stability, cytotoxicity, cellular uptake, and pharmacokinetics of nano-formulations containing curcumin. The obtained results on the behavior of the complex of gradient copoly(2-oxazoline)s and curcumin may contribute to the development of effective next-generation polymeric nanostructures for biomedical applications. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2023 Elektronická adresa https://www.mdpi.com/1999-4923/14/12/2576
Počet záznamů: 1