Počet záznamů: 1
Age-related metabolic and neurodegenerative changes in SAMP8 mice
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SYSNO ASEP 0563881 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Age-related metabolic and neurodegenerative changes in SAMP8 mice Tvůrce(i) Pačesová, A. (CZ)
Holubová, M. (CZ)
Hrubá, L. (CZ)
Strnadová, V. (CZ)
Neprašová, B. (CZ)
Pelantová, H. (CZ)
Kuzma, M. (CZ)
Železná, B. (CZ)
Kuneš, Jaroslav (FGU-C) RID, ORCID
Maletínská, L. (CZ)Zdroj.dok. Aging. - : Impact Journals LLC - ISSN 1945-4589
Roč. 14, č. 18 (2022), s. 7300-7327Poč.str. 28 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Alzheimer’s disease ; senescence accelerated mouse prone 8 ; neuroinflammation ; tau pathology ; insulin resistance Obor OECD Physiology (including cytology) CEP GA20-00546S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000876483400008 EID SCOPUS 85139572689 DOI 10.18632/aging.204284 Anotace The most important risk factor for the development of sporadic Alzheimer's disease (AD) is ageing. Senescence accelerated mouse prone 8 (SAMP8) is a model of sporadic AD, with senescence accelerated resistant mouse (SAMR1) as a control. In this study, we aimed to determine the onset of senescence-induced neurodegeneration and the related potential therapeutic window using behavioral experiments, immunohistochemistry and western blotting in SAMP8 and SAMR1 mice at 3, 6 and 9 months of age. The Y-maze revealed significantly impaired working spatial memory of SAMP8 mice from the 6th month. With ageing, increasing plasma concentrations of proinflammatory cytokines in SAMP8 mice were detected as well as significantly increased astrocytosis in the cortex and microgliosis in the brainstem. Moreover, from the 3rd month, SAMP8 mice displayed a decreased number of neurons and neurogenesis in the hippocampus. From the 6th month, increased pathological phosphorylation of tau protein at Thr231 and Ser214 was observed in the hippocampi of SAMP8 mice. In conclusion, changes specific for neurodegenerative processes were observed between the 3rd and 6th month of age in SAMP8 mice, thus, potential neuroprotective interventions could be applied between these ages. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://doi.org/10.18632/aging.204284
Počet záznamů: 1