Počet záznamů: 1
Structuring and de-structuring of nanovectors from algal lipids. Part 1: physico-chemical characterization
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SYSNO ASEP 0563072 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Structuring and de-structuring of nanovectors from algal lipids. Part 1: physico-chemical characterization Tvůrce(i) Clemente, I. (IT)
D´Aria, F. (IT)
Giancola, C. (IT)
Bonechi, C. (IT)
Šlouf, Miroslav (UMCH-V) RID, ORCID
Pavlova, Ewa (UMCH-V) RID
Rossi, C. (IT)
Ristori, S. (IT)Číslo článku 112939 Zdroj.dok. Colloids and Surfaces B-Biointerfaces. - : Elsevier - ISSN 0927-7765
Roč. 220, December (2022)Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova nanocarriers ; algal lipids ; structure Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000877598400001 EID SCOPUS 85140737134 DOI 10.1016/j.colsurfb.2022.112939 Anotace Lipid nanocarriers are among the most employed systems for drug delivery purposes in several research and industrial sectors, since their favorable properties ensure broad applicability. The design and characterization of these nanosystems are of paramount importance to obtain controlled outcome, since the supramolecular structure and molecular interactions deeply impact the functionality of the resulting aggregates. The choice of the most appropriate formulation for the target of interest relies on in-depth physico-chemical characterization in order to optimize stability, loading rates and sustained release. Several supramolecular architectures suited for carrier development can be obtained from lipid building blocks, by varying lipid composition and packing parameter. In particular, cubosome and liposome aggregates are often used as drug vectors thanks to their high cargo capability and biocompatibility. Moreover, the possibility to employ lipids from natural sources i.e. biomasses to prepare nanosystems makes them especially attractive. In this work, two aggregate types were characterized and compared as drug vectors for poorly water-soluble antioxidants, particularly curcumin and two adjuvants (i.e. tocopherol and piperine). The nanovectors were obtained by extracting lipids from algal biomasses with different lipid composition, and characterized by advanced structural (DLS, SAXS, Cryo-TEM) techniques, spectroscopy (NMR) and calorimetry (ITC). Finally, the structural stability of both aggregate types was evaluated. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2023 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0927776522006233?via%3Dihub
Počet záznamů: 1