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Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice
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SYSNO ASEP 0562222 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice Tvůrce(i) Liu, M. (CN)
Yu, C. (CN)
Zhang, Z. (CN)
Song, M. (CN)
Sun, X. (CN)
Piálek, Jaroslav (UBO-W) RID, ORCID, SAI
Jacob, J. (DE)
Lu, J. (CN)
Cong, L. (CN)
Zhang, H. (CN)
Wang, Y. (CN)
Li, G. (CN)
Feng, Z. (CN)
Du, Z. (CN)
Wang, M. (CN)
Wan, X. (CN)
Wang, D. (CN)
Wang, Y.-L. (CN)
Li, H. (CN)
Wang, Z. (US)
Zhang, B. (CN)
Zhang, Z. (CN)Celkový počet autorů 22 Číslo článku 203 Zdroj.dok. Genome Biology - ISSN 1474-760X
Roč. 23, č. 1 (2022)Poč.str. 23 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Mus musculus ; Domestication ; Positively selected gene ; Genome sequencing ; Alternative splicing Vědní obor RIV EG - Zoologie Obor OECD Zoology CEP GA16-23773S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UBO-W - RVO:68081766 UT WOS 000859917800001 EID SCOPUS 85138951970 DOI 10.1186/s13059-022-02772-1 Anotace Background The laboratory mouse was domesticated from the wild house mouse. Understanding the genetics underlying domestication in laboratory mice, especially in the widely used classical inbred mice, is vital for studies using mouse models. However, the genetic mechanism of laboratory mouse domestication remains unknown due to lack of adequate genomic sequences of wild mice. Results We analyze the genetic relationships by whole-genome resequencing of 36 wild mice and 36 inbred strains. All classical inbred mice cluster together distinctly from wild and wild-derived inbred mice. Using nucleotide diversity analysis, Fst, and XP-CLR, we identify 339 positively selected genes that are closely associated with nervous system function. Approximately one third of these positively selected genes are highly expressed in brain tissues, and genetic mouse models of 125 genes in the positively selected genes exhibit abnormal behavioral or nervous system phenotypes. These positively selected genes show a higher ratio of differential expression between wild and classical inbred mice compared with all genes, especially in the hippocampus and frontal lobe. Using a mutant mouse model, we find that the SNP rs27900929 (T>C) in gene Astn2 significantly reduces the tameness of mice and modifies the ratio of the two Astn2 (a/b) isoforms. Conclusion Our study indicates that classical inbred mice experienced high selection pressure during domestication under laboratory conditions. The analysis shows the positively selected genes are closely associated with behavior and the nervous system in mice. Tameness may be related to the Astn2 mutation and regulated by the ratio of the two Astn2 (a/b) isoforms. Pracoviště Ústav biologie obratlovců Kontakt Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Rok sběru 2023 Elektronická adresa https://genomebiology.biomedcentral.com/articles/10.1186/s13059-022-02772-1
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