Počet záznamů: 1
Association of circulating short chain fatty acid levels with colorectal adenomas and colorectal cancer
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SYSNO ASEP 0560420 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Association of circulating short chain fatty acid levels with colorectal adenomas and colorectal cancer Tvůrce(i) Genua, F. (IE)
Mirković, B. (IE)
Mullee, A. (IE)
Levý, M. (CZ)
Gallagher, W.M. (IE)
Vodička, Pavel (UEM-P) RID
Hughes, D.J. (IE)Zdroj.dok. Clinical Nutrition ESPEN - ISSN 2405-4577
Roč. 46, nov. (2021), s. 297-304Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova short chain fatty acids ; colorectal cancer ; colorectal neoplasms ; microbiome ; gut barrier integrity Obor OECD Microbiology CEP GA20-03997S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 000757020900040 EID SCOPUS 85117707788 DOI 10.1016/j.clnesp.2021.09.740 Anotace Background & aims: Short chain fatty acid (SCFAs) are bacterially derived metabolites suggested to have protective roles against colorectal cancer (CRC) development. However, there is sparse evidence from epidemiological studies in this context. Here, we assessed whether circulating SCFA concentrations varied in patients with colorectal adenomas (CRA) and CRC.
Methods: Levels of seven SCFAs were extracted from plasma samples and determined by gas chromatography for 213 individuals from Ireland and the Czech Republic (CRC, n = 84, CRA, n = 66, controls, n = 63).
Results: In the Irish CRA/CRC cohort, only levels of 2-MethylButyric acid were significantly higher in cancers compared to the adenoma and control groups (p-values = 0.016 and 0.043). Using regression analysis, we observed that levels of Acetic and Propionic acid were associated with an increased CRC risk in the Czech cohort (Odd Ratio (OR): 1.02, 95% Confidence interval (CI): 1.00-1.03, OR: 1.29, 95% CI: 1.05 -1.59, respectively), while i-Valeric and Valeric acid levels were associated with a decreased cancer risk (OR: 0.92, 95% CI: 0.86-0.99, OR: 0.67, 95% CI: 0.44-1.00). In the Irish cohort, levels of SCFAs were not associated with CRC risk.
Conclusions: The association with colorectal neoplasia varied between the studied SCFAs. Future studies need to confirm these findings and address the mechanism of how these acids may promote or prevent colorectal carcinogenesis.Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2024 Elektronická adresa https://clinicalnutritionespen.com/article/S2405-4577(21)01076-7/fulltext
Počet záznamů: 1