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Enzyme-Catalyzed Polymerization Process: A Novel Approach to the Preparation of Polyaniline Colloidal Dispersions with an Immunomodulatory Effect
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SYSNO ASEP 0560260 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Enzyme-Catalyzed Polymerization Process: A Novel Approach to the Preparation of Polyaniline Colloidal Dispersions with an Immunomodulatory Effect Tvůrce(i) Jasenská, D. (CZ)
Kašpárková, V. (CZ)
Vašíček, Ondřej (BFU-R) ORCID, RID
Münster, L. (CZ)
Minařík, A. (CZ)
Kacerova, S. (CZ)
Korabkova, E. (CZ)
Urbánková, L. (CZ)
Vícha, J. (CZ)
Capáková, Z. (CZ)
Falleta, E. (IT)
Della Pina, C. (IT)
Lehocký, M. (CZ)
Skopalová, K. (CZ)
Humpolíček, P. (CZ)Celkový počet autorů 15 Zdroj.dok. Biomacromolecules. - : American Chemical Society - ISSN 1525-7797
Roč. 23, č. 8 (2022), s. 3359-3370Poč.str. 12 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova ANTIOXIDANT ACTIVITY ; NANOPARTICLES ; ANILINE Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology Způsob publikování Omezený přístup Institucionální podpora BFU-R - RVO:68081707 UT WOS 000835322900001 EID SCOPUS 85135599232 DOI 10.1021/acs.biomac.2c00371 Anotace A green, nature-friendly synthesis of polyaniline colloidal particles based on enzyme-assisted oxidation of aniline with horseradish peroxidase and chitosan or poly(vinyl alcohol) as steric stabilizers was successfully employed. Physicochemical characterization revealed formation of particles containing the polyaniline emeraldine salt and demonstrated only a minor effect of polymer stabilizers on particle morphology. All tested colloidal particles showed in vitro antioxidation activity determined via scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. In vitro, they were able to reduce oxidative stress and inhibit the production of reactive oxygen species by neutrophils and inflammatory cytokines by macrophages. The anti-inflammatory effect observed was related to their antioxidant activity, especially in the case of neutrophils. The particles can thus be especially advantageous as active components of biomaterials modulating the early stages of inflammation. In addition to the immunomodulatory effect, the presence of intrinsically conducting polyaniline can impart cell-instructive properties to the particles. The approach to particle synthesis that we employed-an original one using environmentally friendly and biocompatible horseradish peroxidase-represents a smart way of preparing conducting particles with unique properties, which can be further modified by the stabilizers used. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2023 Elektronická adresa https://pubs.acs.org/doi/10.1021/acs.biomac.2c00371
Počet záznamů: 1