Počet záznamů: 1

Males-females differences in the spectrum of chromosomal aberrations in the group of nanocomposites production workers

SYSNO ASEP	0560220
Druh ASEP	K - Konferenční příspěvek (lokální konf.)
Zařazení RIV	Stať ve sborníku
Název	Males-females differences in the spectrum of chromosomal aberrations in the group of nanocomposites production workers
Tvůrce(i)	Rössnerová, Andrea (UEM-P)_RID Pelcová, D. (CZ) Ždímal, Vladimír (UCHP-M)_{RID, ORCID, SAI} Elzeinova, Fatima (UEM-P) Margaryan, Hasmik (UEM-P) Chvojková, Irena (UEM-P) Topinka, Jan (UEM-P)_{RID, ORCID} Schwarz, Jaroslav (UCHP-M)_{RID, ORCID, SAI} Ondráček, Jakub (UCHP-M)_{RID, ORCID, SAI} Koštejn, Martin (UCHP-M)_{RID, SAI, ORCID} Komarc, M. (CZ) Vlčková, Š. (CZ) Fenclová, Z. (CZ) Lischková, L. (CZ) Dvořáčková, Š. (CZ) Rössner ml., Pavel (UEM-P)_{RID, ORCID}
Zdroj.dok.	Nanocon 2019 : Proceedings of the International Conference on Nanomaterials - Research & Application /11./. - Ostrava : Tanger Ltd., 2020 / Shrbená-Váňová J. - ISBN 978-80-87294-95-6 S. 502-507
Poč.str.	6 s.
Forma vydání	Tištěná - P
Akce	International Conference on Nanomaterials - Research and Application, NANOCON 2019 /11./
Datum konání	16.10.2019 - 18.10.2019
Místo konání	Brno
Země	CZ - Česká republika
Typ akce	WRD
Jazyk dok.	eng - angličtina
Země vyd.	CZ - Česká republika
Klíč. slova	DNA damage ; gender ; chromosomal aberrations ; micronuclei ; nanoparticles ; occupational exposure
Obor OECD	Occupational health
CEP	GA18-02079S GA ČR - Grantová agentura ČR
	LO1508 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Institucionální podpora	UEM-P - RVO:68378041 ; UCHP-M - RVO:67985858
UT WOS	000664115400086
EID SCOPUS	85097182983
DOI	10.37904/nanocon.2019.8589
Anotace	An increase in the use of nanomaterials (NM) has been witnessed in many areas of human life. Therefore, assessment of genotoxicity of NM and nanoparticles (NP) is one of the main objectives of genetic toxicology. Despite this fact, human cytogenetic studies following the exposure to NP are still rare. Moreover, no relevant information on possible differences in sensitivity to NP related to gender is available. In this study we periodically (in September 2016, 2017 and 2018; pre-shift and post-shift each year) analyzed a group of workers (both genders), working long time in nanocomposites research, and matched controls. Aerosol exposure monitoring of particulate matter including nano-sized fractions was carried out during working shift. Micronucleus assay using Human Pan Centromeric probes, was applied to distinguish, besides the frequency of total MN in binucleated cells (BNC), also other types of chromosomal damage (losses and breaks). Moreover, whole-chromosome painting (WCP) for autosome #1 and both gonosomes (X and Y) were applied in third sampling period (2018) with the aim to identify the particular structural and numerical chromosomal aberrations. Obtained results showed: (i) differences in the risk of exposure to NP related to individual working processes (welding, smelting and machining); (ii) differences in chemical composition of nano-fraction; (iii) no effect of chronic exposure of NP (total MN) opposite to significant effect of acute exposure; (iv) gender-related DNA damage differences (females seem to be more sensitive to chromosomal losses). Additional data from WCP suggested increased frequency of numerical aberrations in gonosomes.
Pracoviště	Ústav experimentální medicíny
Kontakt	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Rok sběru	2022
Elektronická adresa	https://www.confer.cz/nanocon/2019/92-males-females-differences-in-the-spectrum-of-chromosomal-aberrations-in-the-group-of-nanocomposites-production-workers

Počet záznamů: 1