Počet záznamů: 1
Reduction in the QRS area after cardiac resynchronization therapy is associated with survival and echocardiographic response
- 1.
SYSNO ASEP 0559945 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Reduction in the QRS area after cardiac resynchronization therapy is associated with survival and echocardiographic response Tvůrce(i) Ghossein, M. A. (NL)
van Stipdonk, A. M. W. (NL)
Plešinger, Filip (UPT-D) RID, ORCID, SAI
Kloosterman, M. (NL)
Wouters, P. C. (NL)
Salden, O. A. E. (NL)
Meine, M. (NL)
Maass, A. H. (NL)
Prinzen, F. W. (NL)
Vernooy, K. (NL)Celkový počet autorů 10 Zdroj.dok. Journal of Cardiovascular Electrophysiology. - : Wiley - ISSN 1045-3873
Roč. 32, č. 3 (2021), s. 813-822Poč.str. 10 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova cardiac resynchronization therapy ; echocardiographic response ; heart failure ; QRS area ; QRS area reduction ; survival Vědní obor RIV FA - Kardiovaskulární nemoci vč. kardiochirurgie Obor OECD Cardiac and Cardiovascular systems Způsob publikování Open access Institucionální podpora UPT-D - RVO:68081731 UT WOS 000612475500001 EID SCOPUS 85099840874 DOI 10.1111/jce.14910 Anotace Introduction: Recent studies have shown that the baseline QRS area is associated with the clinical response after cardiac resynchronization therapy (CRT). In this study, we investigated the association of QRS area reduction (∆QRS area) after CRT with the outcome. We hypothesize that a larger ∆QRS area is associated with a better survival and echocardiographic response.
Methods and Results: Electrocardiograms (ECG) obtained before and 2–12 months after CRT from 1299 patients in a multi-center CRT-registry were analyzed. The QRS area was calculated from vectorcardiograms that were synthesized from 12-lead ECGs. The primary endpoint was a combination of all-cause mortality, heart transplantation, and left ventricular (LV) assist device implantation. The secondary endpoint was the echocardiographic response, defined as LV end-systolic volume reduction ≥ of 15%. Patients with ∆QRS area above the optimal cut-off value (62 µVs) had a lower risk of reaching the primary endpoint (hazard ratio: 0.43, confidence interval [CI] 0.33–0.56, p < .001), and a higher chance of echocardiographic response (odds ratio [OR] 3.3,CI 2.4–4.6, p < .0001). In multivariable analysis, ∆QRS area was independently associated with both endpoints. In patients with baseline QRS area ≥109 µVs, survival, and echocardiographic response were better when the ∆QRS area was ≥62 µVs (p < .0001). Logistic regression showed that in patients with baseline QRS area ≥109 µVs, ∆QRS area was the only significant predictor of survival (OR: 0.981, CI: 0.967–0.994, p = .006).
Conclusion: ∆QRS area is an independent determinant of CRT response, especially in patients with a large baseline QRS area. Failure to achieve a large QRS area reduction with CRT is associated with a poor clinical outcome.Pracoviště Ústav přístrojové techniky Kontakt Martina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178 Rok sběru 2023 Elektronická adresa https://onlinelibrary.wiley.com/doi/10.1111/jce.14910
Počet záznamů: 1